The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications
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DOI: 10.1002/bies.202200026
Abstract: The integrated stress response (ISR) is a key determinant of tumorigenesis in response to oncogenic forms of stress like genotoxic, proteotoxic and metabolic stress. ISR relies on the phosphorylation of the translation initiation factor eIF2… read more here.
Keywords: induction mutant; stress response; lung; response induction ... See more keywords