The added value of the 90‐day repeated dose oral toxicity test for industrial chemicals with a low (sub)acute toxicity profile in a high quality dataset: An update
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.09.018
Abstract: ABSTRACT A previous retrospective analysis of substances in the ECHA CHEM database concluded that, for industrial chemicals with a ‘low (sub)acute toxicity profile’, further testing in the 90‐day study is unlikely to change this profile… read more here.
Keywords: day study; toxicity profile; chemicals low; toxicity ... See more keywords
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00009
Abstract: Recently developed high-throughput in vitro assays in combination with computational models could provide alternatives to animal testing. The purpose of the present study was to model the plasma, hepatic, and renal pharmacokinetics of approximately 150… read more here.
Keywords: based pharmacokinetic; renal hepatic; physiologically based; industrial chemicals ... See more keywords