Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Research"
DOI: 10.1038/s41390-020-01271-y
Abstract: Potentially, orally administered antibodies specific to enteric pathogens could be administered to infants to prevent diarrheal infections, particularly in developing countries where diarrhea is a major problem. However, to prevent infection, such antibodies would need… read more here.
Keywords: gastrointestinal tract; igg1; antibody; digestion ... See more keywords
Impact of intrapartum antibiotics on the infant gastrointestinal microbiome: a narrative review
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DOI: 10.1136/archdischild-2021-322590
Abstract: Background The composition of the infant gastrointestinal (GI) microbiome has been linked to adverse long-term health outcomes and neonatal sepsis. Several factors are known to impact the composition of the microbiome, including mode of delivery,… read more here.
Keywords: diversity; infant gastrointestinal; microbiome; gastrointestinal microbiome ... See more keywords
Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2020.00130
Abstract: Oral administration of engineered immunoglobulins has the potential to prevent enteric pathogen-induced diarrhea in infants. To prevent infection, these antibodies need to survive functionally intact in the proteolytic environment of the gastrointestinal tract. This research… read more here.
Keywords: recombinant antibody; vivo digestion; antibody; digestion ... See more keywords