Spotlight on the treatment of infantile fibrosarcoma in the era of neurotrophic tropomyosin receptor kinase inhibitors: International consensus and remaining controversies.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.06.028
Abstract: Targeted neurotrophic tropomyosin receptor kinase (TRK) inhibitors offer a highly specific therapeutic option for patients with infantile fibrosarcoma (IFS) carrying the NTRK gene translocation. International recommendations are needed to define the role of TRK inhibitors… read more here.
Keywords: chemotherapy; neurotrophic tropomyosin; receptor kinase; consensus ... See more keywords
Long term follow-up of congenital infantile fibrosarcoma of the orbital region.
Sign Up to like & getrecommendations! Published in 2022 at "Orbit"
DOI: 10.1080/01676830.2022.2067566
Abstract: We present the long-term follow-up of a case of periorbital congenital infantile fibrosarcoma (CIFS) treated with chemotherapy and surgery. The tumor was detected on a routine prenatal ultrasound at 30 weeks of gestation and diagnosed via… read more here.
Keywords: long term; congenital infantile; term; term follow ... See more keywords
Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2021.1889730
Abstract: Abstract Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors,… read more here.
Keywords: treatment; aortic aneurysm; case; report ... See more keywords
Infantile Fibrosarcoma and Other Spindle Cell Neoplasms of Infancy. A Review of Morphologically Overlapping yet Molecularly Distinctive Entities
Sign Up to like & getrecommendations! Published in 2022 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2021.2024631
Abstract: Abstract Background Regardless of age at presentation, many soft tissue neoplasms have overlapping histopathologic and immunophenotypic features to serve as a diagnostic challenge. Case report We reported a case of a spindle cell neoplasm in… read more here.
Keywords: spindle cell; spindle; cell neoplasms; fibrosarcoma spindle ... See more keywords
Spontaneous Regression in a Patient With Infantile Fibrosarcoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001013
Abstract: Infantile fibrosarcoma usually presents as a rapidly growing mass on the extremities or trunk. We describe spontaneous regression in a 5-month-old female infant with biopsy proven, molecularly confirmed, right leg infantile fibrosarcoma currently at 26… read more here.
Keywords: regression; hematology; patient infantile; regression patient ... See more keywords
Progressive metastatic infantile fibrosarcoma with multiple acquired mutations.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor molecular case studies"
DOI: 10.1101/mcs.a006277
Abstract: Infantile fibrosarcoma is the most common soft-tissue sarcoma in children under the age of 1 yr and is defined molecularly by NTRK fusion proteins. This tumor is known to be locally invasive; however, although rare,… read more here.
Keywords: acquired mutations; fibrosarcoma; multiple acquired; infantile fibrosarcoma ... See more keywords
Evaluation of pan‐TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis‐like neural tumour and histological mimics
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13666
Abstract: Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and ETV6–NTRK3 gene fusion in most cases. Given histological overlap with other spindle‐cell tumours, the diagnosis can be challenging and often requires molecular confirmation. A… read more here.
Keywords: pan trk; trk immunohistochemistry; immunohistochemistry infantile; infantile fibrosarcoma ... See more keywords
A Case of Congenital Infantile Fibrosarcoma of the Bowel Presenting as a Neonatal Intussusception
Sign Up to like & getrecommendations! Published in 2017 at "Pathology International"
DOI: 10.1111/pin.12603
Abstract: Neonatal intussusception of the intestinal tract is rare. However, most neonatal intussusceptions have an organic lead point. For the lead point to be a neoplasm is extremely rare. We report a case that presented with… read more here.
Keywords: neonatal intussusception; intussusception; congenital infantile; case ... See more keywords
Congenital Infantile Fibrosarcoma Involving Pelvic Wall and Thigh Soft Tissues and Placenta, Presenting with Coagulopathy
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric and Developmental Pathology"
DOI: 10.1177/10935266221114017
Abstract: Infantile fibrosarcoma (IF) is a well characterized pediatric malignancy marked by gene rearrangements involving members of the NTRK family. In this report, we present a case of IF that presented in the inguinal region-proximal thigh… read more here.
Keywords: congenital infantile; fibrosarcoma; pelvic wall; fibrosarcoma involving ... See more keywords
Cervical congenital infantile fibrosarcoma: a case report
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-019-1968-0
Abstract: BackgroundCongenital infantile fibrosarcoma is a rare mesenchymal tumor seen in children as well as adults. The congenital variety is rare and out of the reported cases only one case sited in the neck has been… read more here.
Keywords: congenital infantile; histopathology; case; cervical congenital ... See more keywords