Crisis Standard of Care: Management of Infantile Spasms during COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25792
Abstract: The Child Neurology Society collaborated with the Pediatric Epilepsy Research Consortium to issue an online statement April 6, 2020 of immediate recommendations to streamline diagnosis, treatment, and follow up of infantile spasms. The recommendations encourage… read more here.
Keywords: neurology; crisis standard; infantile spasms; management infantile ... See more keywords
Inequities in Therapy for Infantile Spasms: A Call to Action
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26363
Abstract: The aim of this study was to determine whether selection of treatment for children with infantile spasms (IS) varies by race/ethnicity. read more here.
Keywords: spasms call; infantile spasms; inequities therapy; call action ... See more keywords
Infantile spasms in a mosaic monocentric and duplicated SMC 15 patient
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2018.06.009
Abstract: OBJECTIVE To report detail of a patient with infantile spasms whose cytogenetic analysis revealed mosaic monocentric and duplicated supernumerary marker chromosome (SMC) 15. SUBJECT AND METHODS The subject for this case was a 13-month-old girl… read more here.
Keywords: monocentric duplicated; infantile spasms; analysis; mosaic monocentric ... See more keywords
Electroencephalography complexity in infantile spasms and its association with treatment response
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2020.12.006
Abstract: OBJECTIVE To investigate the potential of EEG multiscale entropy and complexity as biomarkers in infantile spasms. METHODS We collected EEG data retrospectively from 16 newly diagnosed patients, 16 age- and gender-matched healthy controls, and 15… read more here.
Keywords: infantile spasms; complexity; response; treatment ... See more keywords
Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.103833
Abstract: Summary Background The infantile spasms syndrome is an early-onset epileptic encephalopathy presenting in the first 2 years of life, often with severe developmental consequences. The role of the gut microbiota and metabolism in infantile spasms… read more here.
Keywords: gut microbiota; kynurenine metabolism; microbiota; infantile spasms ... See more keywords
AQB-565 shows promise in preclinical testing in the model of epileptic spasms during infancy: Head-to-head comparison with ACTH
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.03.004
Abstract: Epileptic spasms during infancy (infantile spasms) represent a serious treatment and social problem despite their rare occurrence. Current treatments include hormonal therapy (adrenocorticotropin-ACTH or corticosteroids) or vigabatrin (per se or in the combination). These treatments… read more here.
Keywords: spasms infancy; infantile spasms; epileptic spasms; aqb 565 ... See more keywords
Genetic heterogeneity in infantile spasms
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.106181
Abstract: Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes… read more here.
Keywords: heterogeneity infantile; genetic heterogeneity; infantile spasms;
Spinal Epidural Lipomatosis: A Rare Complication From Hormonal Therapy for Infantile Spasms.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2019.06.006
Abstract: BACKGROUND Spinal epidural lipomatosis (SEL) represents pathologic overgrowth of extradural adipose tissue in the spinal canal that can result in spinal cord compression. SEL has been associated with excess corticosteroids, whether from exogenous steroid use… read more here.
Keywords: infantile spasms; spinal epidural; epidural lipomatosis; therapy infantile ... See more keywords
Infantile Spasms: Outcome in Clinical Studies.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2020.01.015
Abstract: Children with infantile spasms are likely to have a poor outcome. Outcome measures for infantile spasms include primary response to treatment, relapse of spasms, neurological development, death, and progression to another type of epilepsy (Consensus… read more here.
Keywords: clinical studies; infantile spasms; etiology; treatment ... See more keywords
Definitions and Diagnostic Criteria for Infantile Spasms and West Syndrome - Historical Perspectives and Practical Considerations.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in pediatric neurology"
DOI: 10.1016/j.spen.2021.100893
Abstract: The term infantile spasms has been used inconsistently within the medical literature for decades. We are also without formal consensus on the diagnostic criteria for West syndrome. Author-specific definitions for these terms will determine the… read more here.
Keywords: west syndrome; infantile spasms; criteria infantile; historical perspectives ... See more keywords
Childhood Dystonia-Parkinsonism Following Infantile Spasms-Clinical Clue to Diagnosis in Early Beta-Propeller Protein-Associated Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropediatrics"
DOI: 10.1055/s-0039-1696688
Abstract: INTRODUCTION Beta-propeller protein-associated neurodegeneration (BPAN) is a very rare, X-linked dominant (XLD) inherited member of the neurodegeneration with brain iron accumulation (NBIA) disease family. CASE REPORT We present a female case of BPAN with infantile… read more here.
Keywords: symptomatology; infantile spasms; dystonia; neurodegeneration ... See more keywords