Effects of OP2113 on Myocardial Infarct Size and No Reflow in a Rat Myocardial Ischemia/Reperfusion Model
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07113-7
Abstract: The present study was to determine whether OP2113 could limit myocardial infarction size and the no-reflow phenomenon in a rat myocardial ischemia/reperfusion model. Rat heart–isolated mitochondria (RHM) were used to investigate mitochondrial respiration and mitochondrial… read more here.
Keywords: infarct size; reperfusion; size; ischemia reperfusion ... See more keywords
Mechanical Left Ventricular Unloading to Reduce Infarct Size During Acute Myocardial Infarction: Insight from Preclinical and Clinical Studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09876-3
Abstract: Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality. Pioneering preclinical work reported by Peter Maroko and Eugene Braunwald in 1971 identified oxygen supply and demand are primary determinants of myocardial infarct… read more here.
Keywords: myocardial infarction; infarct size; size; mechanical left ... See more keywords
Influence of Ischemic Pre- and Post-Conditioning on Cardiac Expression of Calcium-Sensing Receptor
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DOI: 10.1007/s12668-016-0316-8
Abstract: Ischemic heart disease is a common cause of patients’ death worldwide. Recently, cardiac pre- and post-conditioning (IPC, IPoC) were indentified to reduce infarct size. Nevertheless, not only infarct size but also post-infarct remodelling is critical… read more here.
Keywords: post conditioning; ipc ipoc; pre post; infarct size ... See more keywords
A high-fat diet rich in corn oil exaggerates the infarct size and memory impairment in rats with cerebral ischemia and is associated with suppressing osteopontin and Akt, and activating GS3Kβ, iNOS, and NF-κB
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00744-2
Abstract: The increase in osteopontin (OPN) levels after stroke induces neural protection by activating Akt signaling and inhibiting GS3Kβ, iNOS, and NF-κB. This study investigated the effect of a high-fat diet rich in corn oil (CO-HFD)… read more here.
Keywords: cerebral ischemia; memory; infarct size; fat ... See more keywords
Relationship between therapeutic effects on infarct size in acute myocardial infarction and therapeutic effects on 1‐year outcomes: A patient‐level analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "American Heart Journal"
DOI: 10.1016/j.ahj.2017.02.028
Abstract: Background While infarct size in patients with ST‐segment elevation myocardial infarction (STEMI) has been generally associated with long‐term prognosis, whether a therapeutic effect on infarct size has a corresponding therapeutic effect on long‐term outcomes is… read more here.
Keywords: treatment; year; infarct size; effect ... See more keywords
CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.09.019
Abstract: BACKGROUND AND AIMS CCN family member 1 (CCN1) has recently been proposed as a novel biomarker of myocardial injury, improving prediction of 30-day and one-year mortality following acute coronary syndromes. Among ST-elevation myocardial infarction (STEMI)… read more here.
Keywords: stemi patients; ccn1; infarct size;
HDAC inhibitors and cardioprotection: Homing in on a mechanism of action
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DOI: 10.1016/j.ebiom.2019.01.015
Abstract: Histone deacetylases (HDACs) are epigenetic regulators with imporConsistent with the observed reductions in apoptotic, oxidative stress tant roles in numerous cellular processes. The HDAC superfamily is divided into four classes based on function and sequence… read more here.
Keywords: vpa; cardiac remodelling; hdac inhibitors; infarct size ... See more keywords
Prognostic significance of QRS fragmentation and correlation with infarct size in patients with anterior ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: Insights from the INFUSE-AMI trial.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.10.051
Abstract: BACKGROUND QRS fragmentation (fQRS) is believed to reflect myocardial scar formation in patients with coronary disease. Whether early formation of fQRS in patients with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI)… read more here.
Keywords: myocardial infarction; pci; infarct size;
Validation of contemporary electrocardiographic indices of area at risk and infarct size in acute ST elevation myocardial infarction (STEMI).
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.10.041
Abstract: BACKGROUND Electrocardiographic (ECG) methods to assess area at risk (AAR) and infarct size (IS) in patients with ST-elevation myocardial infarction (STEMI) have been previously established but not validated against contemporary benchmark Cardiac Magnetic Resonance (CMR)… read more here.
Keywords: stemi; myocardial salvage; infarct size; cmr ... See more keywords
Myocardial Damage in Patients With Deferred Stenting After STEMI: A DANAMI-3-DEFER Substudy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.03.601
Abstract: BACKGROUND Although some studies found improved coronary flow and myocardial salvage when stent implantation was deferred, the DANAMI-3-DEFER (Third DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction) did not show any… read more here.
Keywords: stemi; danami defer; infarct size; deferred stenting ... See more keywords
Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.04.053
Abstract: BACKGROUND Little is known about the role of interleukin (IL)-8 in patients with acute ST-segment elevation myocardial infarction (STEMI). OBJECTIVES The aims of this study were to evaluate, in STEMI patients, the temporal profile of… read more here.
Keywords: infarct size; size; size clinical; association infarct ... See more keywords