Association of lower serum Brain-derived neurotrophic factor levels with larger infarct volumes in acute ischemic stroke
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2017.04.002
Abstract: OBJECTIVE Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission… read more here.
Keywords: brain derived; infarct; serum; dwi infarct ... See more keywords
AMPA Receptor Antagonist Perampanel Ameliorates Post-Stroke Functional and Cognitive Impairments
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.06.043
Abstract: Perampanel (PER), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist, clinically used for seizure control, has been reported to exert neuroprotective effects in experimental models of neurodegenerative diseases. However, few studies have investigated the therapeutic effects of… read more here.
Keywords: post stroke; receptor antagonist; cognitive impairments; infarct volumes ... See more keywords
Abstract WP323: Genetic Knockout of CD38 in Mice Protects Against Ischemic Stroke With Smaller Infarct Volumes and Decreased Motor Impairment
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.wp323
Abstract: Introduction: Endothelial dysfunction is an important mediator of post ischemic injury of the heart and brain following ischemia/reperfusion (I/R). We have reported that CD38 activation in heart I/R models leads to NADPH depletion with endothelial… read more here.
Keywords: motor impairment; infarct volumes; cd38; volume ... See more keywords
Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome
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DOI: 10.1161/strokeaha.122.041351
Abstract: Background: Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However, previous studies used highly invasive… read more here.
Keywords: worsen acute; depolarizations worsen; spreading depolarizations; infarct volumes ... See more keywords