Mechanics‐Resilient HA/SIS‐Based Composite Scaffolds with ROS‐Scavenging and Bacteria‐Resistant Capacity to Address Infected Bone Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202315382
Abstract: To address and regenerate infected bone defects complicated by issues such as inflammation and bone resorption, and to promote bone regeneration, this study focuses on the development of a composite scaffold with reactive oxygen species… read more here.
Keywords: composite scaffold; mechanics; infected bone; bone regeneration ... See more keywords
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201349
Abstract: Repairing infected bone defects is a challenge in the field of orthopedics because of the limited self‐healing capacity of bone tissue and the susceptibility of refractory materials to bacterial activity. Innervation is the initiating factor… read more here.
Keywords: conductive hydrogel; bone; bone regeneration; infected bone ... See more keywords
Zinc-based Tannin-modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300303
Abstract: Treatment of infected bone defects is a major clinical challenge, bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through a facile one-pot hydrothermal reaction of zinc acetate… read more here.
Keywords: bone; activity; bone defect; infected bone ... See more keywords
Temporal Immunomodulatory Hydrogel Regulating the Immune-Osteogenic Cascade for Infected Bone Defects Regeneration.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202514419
Abstract: Early pathogen clearance and immunomodulation are critical for the restoration of infected bone defects. Conventional osteoimmunomodulatory strategies mainly emphasize M2 macrophage‐mediated bone regeneration, neglecting the pivotal role of early‐stage M1 macrophage‐activated immune response in microbial… read more here.
Keywords: temporal immunomodulatory; infected bone; immunomodulatory hydrogel; bone ... See more keywords
Targeting Bacteria‐Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404453
Abstract: The specific mechanisms underlying bacteria‐triggered cell death and osteogenic dysfunction in host bone marrow mesenchymal stem cells (BMSCs) remain unclear, posing a significant challenge to the repair of infected bone defects. This study identifies ferroptosis… read more here.
Keywords: bone marrow; repair; ferroptosis; infected bone ... See more keywords
Ultrasound Activated Piezoelectric Catalysis and Neurogenic Activity for Effective Therapy of MRSA Infected Bone Defects by Phase/Defect‐Engineered Barium Strontium Titanate
Sign Up to like & getrecommendations! Published in 2025 at "Small Methods"
DOI: 10.1002/smtd.202402174
Abstract: Infected bone defects are a growing global health issue, with risks including bone destruction, disability, and even death. The main clinical challenge is the difficulty in simultaneously achieving effective antibacterial action and promoting bone regeneration.… read more here.
Keywords: mrsa infected; infected bone; bone; bone defects ... See more keywords
Transcriptome sequencing profiling identifies miRNA-331-3p as an osteoblast-specific miRNA in infected bone nonunion.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115619
Abstract: Bone nonunion caused by bacterial infection accounts for bone fractures, bone trauma and bone transplantation surgeries. Severe consequences include delayed unions and amputation and result in functional limitations, work disability, and poor quality of life.… read more here.
Keywords: infected bone; bone nonunion; mirna 331;
Self-Adaptive Antibacterial Scaffold with Programmed Delivery of Osteogenic Peptide and Lysozyme for Infected Bone Defect Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19026
Abstract: Bone defects caused by disease or trauma are often accompanied by infection, which severely disrupts the normal function of bone tissue at the defect site. Biomaterials that can simultaneously reduce inflammation and promote osteogenesis are… read more here.
Keywords: lysozyme; bone; scaffold; infected bone ... See more keywords
3D-printed composite scaffold with anti-infection and osteogenesis potential against infected bone defects
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00214k
Abstract: In the field of orthopedics, an infected bone defect is a refractory disease accompanied by bone infection and defects as well as aggravated circulation. There are currently no personalized scaffolds that can treat bone infections… read more here.
Keywords: infected bone; infection; bone defects; plla pearl ... See more keywords
β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for infected bone defect treatment
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277522
Abstract: The repair of infected bone defects remains a clinical challenge. Staphylococcus aureus is a common pathogenic micro-organism associated with such infections. Gentamycin (GM) is a broad spectrum antibiotic that can kill S. aureus in a… read more here.
Keywords: bone; composite scaffolds; release; infected bone ... See more keywords
The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s397316
Abstract: Purpose The repair and treatment of infected bone defects (IBD) is a common challenge faced by orthopedic clinics, medical materials science, and tissue engineering. Methods Based on the treatment requirements of IBD, we utilized multidisciplinary… read more here.
Keywords: biocompatibility osteogenesis; effect; biocompatibility; scaffold ... See more keywords