Nanofocused Scanning X‑ray Fluorescence MicroscopyRevealing an Effect of Heterozygous Hemoglobin S and C on BiochemicalActivities in Plasmodium falciparum-Infected Erythrocytes
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DOI: 10.1021/acs.analchem.9b05111.s001
Abstract: While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying biochemical mechanisms at the single cell level. Using nanofocused scanning… read more here.
Keywords: hemoglobin; ray fluorescence; falciparum infected; infected erythrocytes ... See more keywords
Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1911900116
Abstract: Significance Malaria is one of the deadliest infectious diseases to affect humans, causing over 200 million cases and hundreds of thousands of deaths annually. Its fatal symptoms occur when parasites cause infected human red blood… read more here.
Keywords: type pfemp1; infected erythrocytes; pfemp1; plasmodium falciparum ... See more keywords
Automatic Detection of Malaria Infected Erythrocytes Based on the Concavity Point Identification and Pseudo-Valley Based Thresholding
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DOI: 10.1080/03772063.2020.1787238
Abstract: Automatic malaria diagnosis requires the segmentation of the erythrocytes from the microscopic blood smears images. In this paper, the system for the analysis of the erythrocyte to detect the malar... read more here.
Keywords: erythrocytes based; detection malaria; automatic detection; based concavity ... See more keywords
Impact of Hemoglobin S Trait on Cell Surface Antibody Recognition of Plasmodium falciparum-Infected Erythrocytes in Pregnancy-Associated Malaria
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DOI: 10.1093/ofid/ofz156
Abstract: Abstract Background Sickle cell trait (HbAS) confers partial protection against malaria by reducing the adhesion of Plasmodium falciparum-infected erythrocytes to host receptors, but little is known about its potential protection against placental malaria. Methods Using… read more here.
Keywords: trait; infected erythrocytes; cell surface; cell ... See more keywords
High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death
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DOI: 10.1128/aac.00352-17
Abstract: ABSTRACT Albitiazolium is the lead compound of bisthiazolium choline analogues and exerts powerful in vitro and in vivo antimalarial activities. Here we provide new insight into the fate of albitiazolium in vivo in mice and… read more here.
Keywords: albitiazolium lead; accumulation; new antimalarial; albitiazolium ... See more keywords
Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes
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DOI: 10.1186/s12936-020-03377-4
Abstract: The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. It is widely recognized that the parasite imports low… read more here.
Keywords: plasma; plasminogen; falciparum infected; plasmodium falciparum ... See more keywords
Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes
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DOI: 10.1371/journal.pone.0204177
Abstract: The lack of suitable animal models for the study of cytoadhesion of P. falciparum-infected erythrocytes (IEs) has necessitated in vitro studies employing a range of cell lines of either human tumour origin (e.g., BeWo and… read more here.
Keywords: adhesion; falciparum infected; infected erythrocytes; endothelial cells ... See more keywords
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes
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DOI: 10.3389/fcell.2020.00080
Abstract: Sphingosine-1-phosphate (S1P), a bioactive lipid mediator is involved in an array of biological processes and linked to pathological manifestations. Erythrocyte is known as the major reservoir for S1P as they lack S1P-degrading enzymes (S1P lyase… read more here.
Keywords: infected erythrocytes; biology; sphingosine; s1p ... See more keywords
Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
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DOI: 10.3389/fimmu.2018.03126
Abstract: Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce malaria transmission and are thus attractive targets for malaria control. However, very little is known about human immune responses to gametocytes present in human… read more here.
Keywords: antibodies gametocyte; surface; gametocyte infected; gametocyte ies ... See more keywords
Bradykinin Sequestration by Plasmodium berghei Infected Erythrocytes Conditions B2R Signaling and Parasite Uptake by Fetal Trophoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03106
Abstract: Plasmodium infection during pregnancy causes placental malfunction reducing fetus sustainability and leading to abortions, stillbirths, low birth weight or premature delivery. Accumulation of infected erythrocytes (IE) in the placenta is a key factor in placental… read more here.
Keywords: sequestration; b2r signaling; infected erythrocytes; berghei ... See more keywords
Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis
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DOI: 10.7554/elife.51546
Abstract: In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new… read more here.
Keywords: type rosetting; infected erythrocytes; plasmodium infected; igfbp7 ... See more keywords