Andrographolide exerts anti‐inflammatory effects in Mycobacterium tuberculosis‐infected macrophages by regulating the Notch1/Akt/NF‐κB axis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma1119-584rrr
Abstract: Tuberculosis is a serious public health problem aggravated by the slow progress in the development of new anti‐tuberculosis drugs. The hyper‐reactive TB patients have suffered from chronic inflammation which could cause deleterious effects on their… read more here.
Keywords: infected macrophages; mycobacterium tuberculosis; anti inflammatory; tuberculosis ... See more keywords
A Novel Approach in Treatment of Tuberculosis by Targeting Drugs to Infected Macrophages Using Biodegradable Nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2695-5
Abstract: Mycobacterium tuberculosis, the causative agent of tuberculosis is now causing death of more than 10 million people. Because of the development of drug-resistant TB, drug delivery to the infected site through nanoparticle had been studied… read more here.
Keywords: drug delivery; drug; infected macrophages; tuberculosis ... See more keywords
In silico studies and evaluation of antiparasitic role of a novel pyruvate phosphate dikinase inhibitor in Leishmania donovani infected macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.12.011
Abstract: The present work deals with the identification and characterization of a novel inhibitor Z220582104, specific to pyruvate phosphate dikinase, for leishmanicidal activities against free promastigotes and intracellular amastigotes. We have used structure-based drug designing approaches… read more here.
Keywords: inhibitor; phosphate dikinase; pyruvate phosphate; infected macrophages ... See more keywords
Tanshinone IIA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-(H37Ra-) infected macrophages by inhibiting endoplasmic reticulum stress.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114595
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Tanshinone IIA (Tan), extracted from Salvia miltiorrhiza Bunge, is a perennial herbal plant widely used as a folk remedy in Asian countries. Several studies have proved that Tanshinone IIA possesses many biological activities,… read more here.
Keywords: inflammasome activation; pyroptosis; tanshinone iia; infected macrophages ... See more keywords
17β-estradiol modulates the expression of hormonal receptors on THP-1 T. gondii-infected macrophages and monocytes in an AKT and ERK-dependent manner.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2021.111433
Abstract: Toxoplasma gondii (T. gondii) is a parasite common in pregnancy. Monocytes and macrophages are a significant immunologic barrier against T. gondii by boosting up inflammation. This outcome is highly regulated by signaling pathways such as… read more here.
Keywords: expression hormonal; gondii infected; hormonal receptors; gondii ... See more keywords
Synchrotron-Infrared Microspectroscopy of Live Leishmania major Infected Macrophages and Isolated Promastigotes and Amastigotes.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04004
Abstract: The prevalence of neglected tropical diseases (NTDs) is advancing at an alarming rate. The NTD leishmaniasis is now endemic in over 90 tropical and sub-tropical low socioeconomic countries. Current diagnosis for this disease involves serological… read more here.
Keywords: synchrotron infrared; infrared microspectroscopy; microscopy; leishmania major ... See more keywords
Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.06.30.498265
Abstract: HIV-1 Envelope (Env) conformation determines the susceptibility of infected CD4+ T cells to Antibody Dependent Cellular Cytotoxicity (ADCC). Upon interaction with CD4, Env adopts more “open” conformations, exposing ADCC epitopes. HIV-1 limits Env-CD4 interaction and… read more here.
Keywords: antibody dependent; cd4; infected macrophages; cellular cytotoxicity ... See more keywords
Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.1033
Abstract: Chlamydia muridarum and Chlamydia caviae have equivalent growth rates in mouse epithelial cells but only C. muridarum replicates inside mouse macrophages, while C. caviae does not. Macrophages infected with C. muridarum or C. caviae were… read more here.
Keywords: signaling pathways; pathways initiated; infected macrophages; caviae ... See more keywords
Elucidation of the signalling pathways for enhanced exosome release from Mycobacterium‐infected macrophages and subsequent induction of differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13561
Abstract: Exosomes are extracellular vesicles released by all cell types; perform several important functions such as cell‐to‐cell communication, growth, differentiation and so on. Exosomes elicit several signalling mechanisms as they carry information in the form of… read more here.
Keywords: elucidation signalling; mycobacterium; infected macrophages; release ... See more keywords
Implication of the IL-10-Expression Signature in the Pathogenicity of Leptospira-Infected Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02595-21
Abstract: Activation of macrophages by Leptospira spp. infection is thought to be involved in the pathogenesis of leptospirosis. To evaluate the innate macrophage responses to Leptospira spp., specifically pathogenic versus nonpathogenic Leptospira spp., we characterized the… read more here.
Keywords: leptospira infected; infection; infected macrophages; nonpathogenic leptospira ... See more keywords
Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201846613
Abstract: Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage‐derived EVs through an… read more here.
Keywords: extracellular vesicles; deliver mycobacterium; vesicles deliver; infected macrophages ... See more keywords