Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0576-7
Abstract: BackgroundDifferences in plasma protein levels observed between children and adults can alter the extent of xenobiotic binding in plasma, resulting in divergent patterns of exposure.ObjectiveThis study aims to quantify the ontogeny of α1-acid glycoprotein in… read more here.
Keywords: fold error; acid glycoprotein; average fold; infected subjects ... See more keywords
Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2017.11.010
Abstract: INTRODUCTION Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association… read more here.
Keywords: ham; htlv infected; ham tsp; hla kir ... See more keywords
Prevalence of Helicobacter pylori infection in sexual partners of H. pylori-infected subjects: Role of gastroesophageal reflux
Sign Up to like & getrecommendations! Published in 2018 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640618800628
Abstract: Background Helicobacter pylori is transmitted through faecal-oral or oral-oral routes. Whether H. pylori infection is more prevalent in sexual partners of H. pylori-infected subjects is unclear. Objective We evaluated 1) the prevalence of H. pylori… read more here.
Keywords: infection; prevalence; sexual partners; infected subjects ... See more keywords
Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1617-1
Abstract: BackgroundMaraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different… read more here.
Keywords: hbv vaccine; mvc cart; infected subjects; therapy ... See more keywords
Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects
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DOI: 10.1371/journal.pone.0204974
Abstract: Background The nucleotide analog AL-335 is a pangenotypic hepatitis C virus (HCV) nonstructural protein (NS)5B inhibitor being evaluated as treatment for chronic HCV infection. Methods This three-part randomized, double-blind study evaluated the safety and pharmacokinetics… read more here.
Keywords: gt1 infected; healthy volunteers; infected subjects; hepatitis virus ... See more keywords
Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
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DOI: 10.3389/fimmu.2020.581307
Abstract: Background We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could… read more here.
Keywords: derived suppressor; immunodiscordance; infected subjects; myeloid derived ... See more keywords
Immuno-Diagnosis of Active Tuberculosis by a Combination of Cytokines/Chemokines Induced by Two Stage-Specific Mycobacterial Antigens: A Pilot Study in a Low TB Incidence Country
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.842604
Abstract: Active tuberculosis (aTB) remains a major killer from infectious disease, partially due to delayed diagnosis and hence treatment. Classical microbiological methods are slow and lack sensitivity, molecular techniques are costly and often unavailable. Moreover, available… read more here.
Keywords: infected subjects; hbha; validation; non infected ... See more keywords
Gamma-Delta T-Cell Phenotype and Function in DAA-Treated HIV-HCV Co-Infected and HCV-Mono-Infected Subjects
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DOI: 10.3390/v14081594
Abstract: HIV-HCV co-infected subjects are at risk of liver fibrosis which may be linked to immune imbalances. Direct-acting antivirals (DAAs) represent the mainstay of HCV treatment in co-infected individuals, yet their effects on immune cell populations… read more here.
Keywords: infected subjects; cell; function; hiv hcv ... See more keywords