Radiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging
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DOI: 10.1007/s00044-017-2009-4
Abstract: The aim of this study was to prepare 99mTc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99mTc and its biological efficacy as a potential radio tracer for… read more here.
Keywords: biodistribution 99mtc; sulfamethoxazole; infection imaging; 99mtc sulfamethoxazole ... See more keywords
Synthesis and Bioevaluation of Novel Technetium-99m-Labeled Complexes with Norfloxacin HYNIC Derivatives for Bacterial Infection Imaging.
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DOI: 10.1021/acs.molpharmaceut.2c00830
Abstract: To seek a novel 99mTc-labeled quinolone derivative for bacterial infection SPECT imaging that aims to lower nontarget organ uptake, a novel norfloxacin 6-hydrazinoicotinamide (HYNIC) derivative (HYNICNF) was designed and synthesized. It was radiolabeled with different… read more here.
Keywords: hynicnf; infection; novel; infection imaging ... See more keywords
Preclinical Research Highlighting Contemporary Targeting Mechanisms of Radiolabelled Compounds for PET Based Infection Imaging.
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DOI: 10.1053/j.semnuclmed.2023.03.001
Abstract: It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, it must be evaluated if… read more here.
Keywords: infection; immuno pet; infection imaging; medicine ... See more keywords
Radiosynthesis, quality control, biodistribution, and infection-imaging study of a new 99mTc-labeled ertapenem radiopharmaceutical
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DOI: 10.3389/fchem.2022.1020387
Abstract: Ertapenem is a member of carbapenem antibiotics used for the treatment of moderate-to-severe intra-abdominal, urinary tract, acute pelvic, and post-surgical gynecologic infections. The antibacterial activity of ertapenem is mediated through binding to penicillin-binding proteins which… read more here.
Keywords: biodistribution; quality control; infection; radiosynthesis quality ... See more keywords
Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives
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DOI: 10.3389/fmed.2022.819702
Abstract: COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging modalities has always played… read more here.
Keywords: latest developments; radiopharmaceuticals infection; highlights latest; medicine ... See more keywords
Synthesis and Evaluation of Novel Norfloxacin Isonitrile 99mTc Complexes as Potential Bacterial Infection Imaging Agents
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DOI: 10.3390/pharmaceutics13040518
Abstract: To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a [99mTc][Tc(I)]+ core to obtain [99mTc]Tc-CN4NF and… read more here.
Keywords: bacterial infection; infection imaging; infection; imaging agents ... See more keywords