New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21494
Abstract: Polymyxin B and colistin (polymyxin E) are bactericidal pentacationic lipopeptides that act specifically on Gram‐negative bacteria, first by disrupting their outermost permeability barrier, the outer membrane (OM), and then damaging the cytoplasmic membrane. The discovery… read more here.
Keywords: animal infection; infection; polymyxin; infection models ... See more keywords
Exploitation of Drosophila Infection Models to Evaluate Antibacterial Efficacy of Phages.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8940-9_15
Abstract: Nonmammalian infection models have been exploited to understand the various aspects of host-pathogen interactions and also provided innovative research platforms for identification of virulence factors, screening for antimicrobial hits, and evaluation of antimicroial efficacy. Here we… read more here.
Keywords: drosophila infection; exploitation drosophila; infection; efficacy ... See more keywords
Comparison of Sheep, Goats, and Calves as Infection Models for Mycobacterium avium subsp. paratuberculosis.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2020.110060
Abstract: Animal infection models to study Mycobacterium avium subsp. paratuberculosis (MAP) infection are useful for evaluating the efficacy of vaccines and other therapeutics for the prevention or treatment of infection. The goal of the present study… read more here.
Keywords: goats calves; infection; mycobacterium avium; infection models ... See more keywords
3D bioprinting of E. coli MG1655 biofilms on human lung epithelial cells for building complex in vitro infection models.
Sign Up to like & getrecommendations! Published in 2023 at "Biofabrication"
DOI: 10.1088/1758-5090/acd95e
Abstract: Biofilm-associated infections are causing over half a million deaths each year, raising the requirement for innovative therapeutic approaches. For developing novel therapeutics against bacterial biofilm infections, complex in vitro models that allow to study drug… read more here.
Keywords: vitro; infection models; vitro infection; coli mg1655 ... See more keywords
Investigations on In Vivo Pharmacokinetic/Pharmacodynamic Determinants of Fosfomycin in Murine Thigh and Kidney Infection Models.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0119
Abstract: Background: Amidst the era of widespread resistance, there has been a renewed interest in older antibiotics such as fosfomycin, owing to its activity against certain resistant Gram-negative pathogens, including multidrug-resistant variants expressing extended spectrum β-lactamases… read more here.
Keywords: infection models; thigh kidney; infection; murine thigh ... See more keywords
Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs
Sign Up to like & getrecommendations! Published in 2023 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuad011
Abstract: Abstract Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious disease models, due to ease of use and the presence of an innate immune system functionally similar to that of vertebrates. Here,… read more here.
Keywords: intracellular bacteria; infection models; bacteria pathogen; galleria mellonella ... See more keywords
Pneumococcal Colonization and Virulence Factors Identified Via Experimental Evolution in Infection Models
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab018
Abstract: Abstract Streptococcus pneumoniae is a commensal of the human nasopharynx and a major cause of respiratory and invasive disease. We examined adaptation and evolution of pneumococcus, within nasopharynx and lungs, in an experimental system where… read more here.
Keywords: evolution; virulence; experimental evolution; colonization ... See more keywords
Pharmacodynamics of Temocillin in Neutropenic Murine Infection Models
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01433-22
Abstract: Temocillin is used for the treatment of various infections caused by Enterobacterales. The pharmacokinetic (PK)/pharmacodynamic (PD) index that is best correlated with the activity of beta-lactams is the percentage of time that the unbound concentration… read more here.
Keywords: infection models; pneumoniae; infection; lung infection ... See more keywords
A renewed tool kit to explore Chlamydia pathogenesis: from molecular genetics to new infection models
Sign Up to like & getrecommendations! Published in 2019 at "F1000Research"
DOI: 10.12688/f1000research.18832.1
Abstract: Chlamydia trachomatis is the most prevalent sexually transmitted bacterial pathogen and the leading cause of preventable blindness in the developing world. C. trachomatis invades the epithelium of the conjunctiva and genital tract and replicates within… read more here.
Keywords: genetics; infection; tool kit; trachomatis ... See more keywords
Advances and gaps in SARS-CoV-2 infection models
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010161
Abstract: The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are… read more here.
Keywords: infection models; gaps sars; cov infection; advances gaps ... See more keywords
The challenges of Plasmodium vivax human malaria infection models for vaccine development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1006954
Abstract: Controlled Human Malaria Infection models (CHMI) have been critical to advancing new vaccines for malaria. Stringent and safe preparation of a challenge agent is key to the success of any CHMI. Difficulty producing the Plasmodium… read more here.
Keywords: infection models; malaria infection; development; vaccine development ... See more keywords