Infectivity assay for detection of SARS‐CoV‐2 in samples from patients with COVID‐19
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DOI: 10.1002/jmv.27145
Abstract: Since the coronavirus disease 2019 (COVID‐19) outbreak, laboratory diagnosis has mainly been conducted using reverse‐transcription polymerase chain reaction (RT‐PCR). Detecting the presence of an infectious virus in the collected sample is essential to analyze if… read more here.
Keywords: virus titers; infectivity assay; patients covid; infectious virus ... See more keywords
Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103637
Abstract: Background The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised. Methods We measured infectious viral release, antibodies and cytokines in 426 PCR+ nasopharyngeal swabs from individuals harboring… read more here.
Keywords: infectious virus; sars cov; nasopharyngeal swabs; alpha ... See more keywords
Oral Susceptibility of Japanese Culicoides (Diptera: Ceratopogonidae) Species to Akabane Virus
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DOI: 10.1093/jme/tjy201
Abstract: Abstract To test their virus susceptibility and capacity as transmission vectors, Japanese Culicoides species were artificially fed a mixture of Akabane virus (AKAV) and bovine blood, and virus recovery was attempted from infected midges 9–11… read more here.
Keywords: susceptibility; japanese culicoides; infected midges; infectious virus ... See more keywords
Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
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DOI: 10.1093/ofid/ofac192
Abstract: Abstract Background The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals… read more here.
Keywords: breakthrough infections; virus shedding; infectious virus; sars cov ... See more keywords
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abl7430
Abstract: There is an urgent need for an effective, oral, direct-acting therapeutic to block transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent progression to severe coronavirus disease 2019 (COVID-19). In a phase 2a… read more here.
Keywords: rna clearance; molnupiravir; infectious virus; sars cov ... See more keywords
Actin-Dependent Nonlytic Rotavirus Exit and Infectious Virus Morphogenetic Pathway in Nonpolarized Cells
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DOI: 10.1128/jvi.02076-17
Abstract: ABSTRACT During the late stages of rotavirus morphogenesis, the surface proteins VP4 and VP7 are assembled onto the previously structured double-layered virus particles to yield a triple-layered, mature infectious virus. The current model for the… read more here.
Keywords: rotavirus; nonpolarized cells; actin dependent; infectious virus ... See more keywords
Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort study
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DOI: 10.1371/journal.ppat.1010802
Abstract: The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal… read more here.
Keywords: symptom onset; viral shedding; vaccination; infectious virus ... See more keywords
Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccinees
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DOI: 10.3201/eid2805.220197
Abstract: To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in Japan during November 29–December 18, 2021. Vaccinees… read more here.
Keywords: omicron variant; virus; virus shedding; infectious virus ... See more keywords
Following Acute Encephalitis, Semliki Forest Virus is Undetectable in the Brain by Infectivity Assays but Functional Virus RNA Capable of Generating Infectious Virus Persists for Life
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DOI: 10.3390/v10050273
Abstract: Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthralgia, myalgia and more severely, encephalitis. In the mouse, peripheral infection with Semliki Forest virus (SFV) results in encephalitis. With… read more here.
Keywords: virus rna; infectious virus; brain; virus ... See more keywords