Multiple assessments of non‐inferiority trials with ordinal endpoints
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DOI: 10.1002/sim.9660
Abstract: Non‐inferiority (NI) trials are implemented when there is a practical demand to search for alternatives to standard therapies, such as to reduce side effects. An experimental treatment is considered non‐inferior to the standard treatment when… read more here.
Keywords: inferiority; latent variable; non inferiority; inferiority trials ... See more keywords
Non-efficacy benefits and non-inferiority margins: a scoping review of contemporary high-impact non-inferiority trials in clinical cardiology
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DOI: 10.1007/s10654-021-00820-x
Abstract: Randomized non-inferiority trials are designed to study whether an experimental treatment (or diagnostic test) is not unacceptably worse in terms of efficacy compared to the standard of care, whilst providing specific advantages over the standard… read more here.
Keywords: non inferiority; cardiology; non efficacy; inferiority ... See more keywords
Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy?
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DOI: 10.1007/s11606-017-4191-y
Abstract: E ach week, a practicing physician may read the latest medical journal and find a new intervention claiming to be non-inferior to a therapy she uses, while offering the advantage of freedom from monitoring, lower… read more here.
Keywords: medicine; non inferiority; medicine practice; trials medicine ... See more keywords
Statistical methods for non-adherence in non-inferiority trials: useful and used? A systematic review
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DOI: 10.1136/bmjopen-2021-052656
Abstract: Background In non-inferiority trials with non-adherence to interventions (or non-compliance), intention-to-treat and per-protocol analyses are often performed; however, non-random non-adherence generally biases these estimates of efficacy. Objective To identify statistical methods that adjust for the… read more here.
Keywords: inferiority; statistical methods; inferiority trials; non inferiority ... See more keywords
Commentary on Bamat et al.
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DOI: 10.1177/1740774520941442
Abstract: This issue of Clinical Trials presents noteworthy insights into protocol adherence and hypothesis confirmation in non-inferiority randomized trials. Noninferiority trials usually compare two interventions with similar expected efficacy, but possible differences in convenience or cost.… read more here.
Keywords: superiority; inferiority trials; non inferiority; hypothesis ... See more keywords