Interferon-gamma (INFG), an important marker of response to immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) and melanoma patients.
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DOI: 10.1200/jco.2017.35.15_suppl.11504
Abstract: 11504Background: PD-L1 can be induced by oncogenic signals or up-regulated via INFG in a STAT1- and NFκB-dependent manner. STAT3 opposes STAT1-mediated anti-tumor immune responses. I kappa B kinase epsilon (IKBKE) is an interferon signaling inducer.… read more here.
Keywords: melanoma; icb; infg; nsclc melanoma ... See more keywords