Multiplex Immunofluorescence for Detection of Spatial Distributions of Infiltrating T Cells Within Different Regions of Hepatic Lobules During Liver Transplantation Rejection.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01574-0
Abstract: It remains unclear as to whether there are differences that exist in the types and functional status of immune cells within different areas of the liver lobules after rejection of liver transplantation. The composition of… read more here.
Keywords: cells within; rejection; liver transplantation; infiltrating cells ... See more keywords
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.01.022
Abstract: T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-seq) to chart the gene expression and clonal landscape… read more here.
Keywords: cd161; single cell; analysis; cell ... See more keywords
Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2016168118
Abstract: Significance Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive. Self-specific CD8+ T cells are particular characteristics of tumor types with lower tumor mutation burden and poorer… read more here.
Keywords: stimulation; tumor infiltrating; antigen; innate immune ... See more keywords
Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1393596
Abstract: ABSTRACT Pancreatic Ductal Adenocarcinoma (PDA) is characterized by a complex tumor microenvironment that supports its progression, aggressiveness and resistance to therapies. The delicate interplay between cancer and immune cells creates the conditions for PDA development,… read more here.
Keywords: phenotype; tumor associated; anti tumor; infiltrating cells ... See more keywords
Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma
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DOI: 10.1080/2162402x.2019.1571388
Abstract: ABSTRACT As a major cellular component in tumor microenvironment, the distribution, frequency, and prognostic significance of infiltrating B cell subsets in hepatocellular carcinoma (HCC) remain controversial. Using tyramide signal amplification (TSA) based fluorescent multiplexed immunohistochemistry… read more here.
Keywords: infiltrating cells; hepatocellular carcinoma; cell subsets; significance ... See more keywords
Single‐cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer
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DOI: 10.1111/imm.13568
Abstract: B cells constitute a major component of infiltrating immune cells in colorectal cancer (CRC). However, the characteristics of B cells and their clinical significance remain unclear. In this study, using single‐cell RNA sequencing and multicolour… read more here.
Keywords: cell; single cell; colorectal cancer; cells colorectal ... See more keywords
Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer
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DOI: 10.1126/scitranslmed.abb0192
Abstract: γδ T cells are clonotypically distinct in ascites and tumors of patients with ovarian cancer and their functionality correlates with clinical outcome. An innate response to ovarian cancer Favorable outcomes for patients with epithelial ovarian… read more here.
Keywords: tumor infiltrating; ovarian cancer; cancer; cell ... See more keywords
Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005925
Abstract: Background Although immune checkpoint blockade (ICB) and adoptive T cell transfer (ACT) therapy have achieved impressive clinical outcomes, majority of patients do not respond to immunotherapy. Tumor-infiltrating T cells, a critical factor to immunotherapy, is… read more here.
Keywords: tumor infiltrating; immunotherapy; tumor; 99mtc sum ... See more keywords
Abstract 4055: CD40L stimulates melanoma infiltrating B cells and enhances ex vivo TIL expansion
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DOI: 10.1158/1538-7445.am2023-4055
Abstract: Adoptive transfer of tumor infiltrating lymphocytes (TIL) is a feasible and effective therapy for melanoma and lung cancer[1,2]. Multiple factors may determine the quality of the TIL product including components of the tumor microenvironment. In… read more here.
Keywords: cd40l; expansion; melanoma infiltrating; til expansion ... See more keywords
Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
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DOI: 10.1172/jci120859
Abstract: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after infiltrating the kidney. The current paradigm suggests that kidney-infiltrating T… read more here.
Keywords: lupus nephritis; murine lupus; lupus; infiltrating cells ... See more keywords
Imaging of tumor infiltrating T cells with an anti-CD8 minibody (Mb) 89Zr-IAB22M2C, in advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24160
Abstract: e24160Background: The degree of tumor infiltration by CD8 T cells is associated with favorable outcomes to immunotherapy. Biopsies to assess T cell infiltration are invasive and may not capture het... read more here.
Keywords: imaging tumor; cd8; cells anti; tumor infiltrating ... See more keywords