Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.10.005
Abstract: Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited… read more here.
Keywords: csf1r; infiltration tumors; associated fibroblasts; effect ... See more keywords
Barriers to immune cell infiltration in tumors
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006401
Abstract: Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to… read more here.
Keywords: infiltration; cell; cell infiltration; immune cell ... See more keywords
Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0387
Abstract: Loss of nitric oxide synthase is shown to debilitate cytotoxic T cells in the therapeutic setting. Although nitric oxide is typically characterized as immunosuppressive, these data highlight its key intrinsic role in modulating T-cell tumor… read more here.
Keywords: cell; infiltration tumors; nitric oxide; tumors regulated ... See more keywords