Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02082-2
Abstract: Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of effective treatment. Microglia are a major component of the innate immune system, and they respond to acute brain injury… read more here.
Keywords: inflammasome; intracerebral hemorrhage; neuroinflammation; therapeutic targets ... See more keywords
Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104763
Abstract: OBJECTIVES To investigate the underlying mechanism between diabetic periodontitis and NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis. DESIGN Experimental models of diabetes-associated periodontitis were implemented in db/db mice. We detected NLRP3 inflammasome… read more here.
Keywords: inflammasome; mediated pyroptosis; expression; diabetic periodontitis ... See more keywords
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Experimental neurology"
DOI: 10.1016/j.expneurol.2021.113952
Abstract: As a primary nonpharmacological tool, exercise training is neuroprotective after experimental ischemic stroke by relieving neuroinflammation. However, the specific mechanism of which and anti-inflammatory effect of exercise at different intensities require in-depth investigations. To explore… read more here.
Keywords: exercise induced; inflammasome; pyroptosis; exercise ... See more keywords
The role of inflammasome activation in Triptolide-induced acute liver toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105754
Abstract: Triptolide (TP), the major active compound derived from the traditional Chinese medicine Tripterygium wilfordii Hook. F, possesses an excellent pharmacological profile of immunomodulatory and anti-tumor activities. However, the application of TP was restricted due to… read more here.
Keywords: acute liver; inflammasome; liver toxicity; activation ... See more keywords
How ICE lights the pyroptosis fire
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2016.157
Abstract: Immune antigen-presenting cells and skin and mucosal epithelia vigorously respond to invasive microbial infection. When NOD-like receptors (NLRs) or AIM2-like receptors (ALRs) in the immune cell cytosol sense microbial products, they assemble the canonical inflammasome,… read more here.
Keywords: inflammasome; ice; pyroptosis fire; ice lights ... See more keywords
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00917-6
Abstract: Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis. Here we show that LPS-mediated activation of… read more here.
Keywords: caspase; cellular senescence; inflammasome; cytoplasmic innate ... See more keywords
Walking over the inflammasome
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0292-8
Abstract: The NLRP3 inflammasome contributes to pathogenic inflammation in a broad range of diseases, making it a highly relevant drug target. Two studies published in this issue found an inhibitor of NLRP3 inflammasome activation to directly… read more here.
Keywords: inflammasome; biology; walking inflammasome;
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21198-z
Abstract: Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2AkitaxVEGF+/−), which demonstrates hyperglycemia, vascular hyperpermeability and… read more here.
Keywords: inflammasome; diabetic retinopathy; neovascularization; nlrp3 inflammasome ... See more keywords
Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Brain pathology"
DOI: 10.1111/bpa.13142
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease that destroys memory and cognitive function. Inflammasome activation has been suggested to play a critical role in the neuroinflammatory response in AD progression, but the cell-type expression… read more here.
Keywords: identification inflammasome; inflammasome; alzheimer disease; expression ... See more keywords
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways
Sign Up to like & getrecommendations! Published in 2023 at "Immunological Reviews"
DOI: 10.1111/imr.13186
Abstract: Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates two major functions in innate immunity: (i) elimination of intracellular replicative… read more here.
Keywords: gsdmd; cell death; cell; inflammasome ... See more keywords
Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15523
Abstract: Uric acid crystal is known to activate the NLRP3 inflammasome and to cause tissue damages, which can result in many diseases, such as gout, chronic renal injury and myocardial damage. Meanwhile, soluble uric acid (sUA),… read more here.
Keywords: uric acid; inflammasome; myocardial damage; sua ... See more keywords