BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202070033
Abstract: Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy… read more here.
Keywords: inflammasome activation; brca1; mammary tumor; tumor metastasis ... See more keywords
Targeting Inflammasomes to Treat Neurological Diseases
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DOI: 10.1002/ana.26158
Abstract: Inflammasomes are multimeric protein complexes that can sense a plethora of microbe‐ and damage‐associated molecular signals. They play important roles in innate immunity and are key regulators of inflammation in health and disease. Inflammasome‐mediated processing… read more here.
Keywords: inflammasomes treat; inflammasome activation; disease; targeting inflammasomes ... See more keywords
Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948254
Abstract: Inflammasomes are multimeric protein complex that assemble in the cytosol upon microbial infection or cellular stress. Upon activation, inflammasomes drive the maturation of proinflammatory cytokines, IL‐1β and IL‐18, and also activate the pore‐forming protein, gasdermin… read more here.
Keywords: inflammasome activation; apoptosis; activation; pannexin ... See more keywords
The TLR‐chaperone CNPY3 is a critical regulator of NLRP3‐inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149612
Abstract: TLRs mediate the recognition of microbial and endogenous insults to orchestrate the inflammatory response. TLRs localize to the plasma membrane or endomembranes, depending on the member, and rely critically on ER‐resident chaperones to mature and… read more here.
Keywords: role cnpy3; cnpy3; inflammasome activation; tlrs ... See more keywords
ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5‐12‐16L1 complex assembly and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149764
Abstract: NLRP3 inflammasome activation is regulated by autophagy, a process tightly controlled by the ATG16L family proteins. However, the inside mechanisms remain elusive. Although the autophagy‐related protein ATG16L1 has been well characterized, regulation and biological functions… read more here.
Keywords: atg5 16l1; 16l1 complex; inflammasome activation; complex assembly ... See more keywords
The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24174
Abstract: The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi‐protein complex responsible for the activation of caspase‐1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL‐1β and IL‐18, and pyroptotic… read more here.
Keywords: potassium; channel thik; inflammasome activation; activation ... See more keywords
STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss
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DOI: 10.1002/jbmr.4756
Abstract: Signal transducer and activator of transcription 3 (STAT3), a cytokine‐responsive transcription factor, is known to play a role in immunity and bone remodeling. However, whether and how STAT3 impacts macrophage NLR family pyrin domain containing… read more here.
Keywords: bone; stat3; inflammasome activation; inflammatory bone ... See more keywords
Dexmedetomidine alleviates lipopolysaccharide‐induced acute kidney injury by inhibiting the NLRP3 inflammasome activation via regulating the TLR4/NOX4/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29173
Abstract: Dexmedetomidine (DEX) prevents kidney damage caused by sepsis, but the mechanism of this effect remains unclear. In this study, the protective molecular mechanism of DEX in lipopolysaccharide (LPS)‐induced acute kidney injury was investigated and its… read more here.
Keywords: inflammasome activation; dex; damage; nlrp3 inflammasome ... See more keywords
Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome
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DOI: 10.1002/ptr.7118
Abstract: The NLR family, pyrin domain‐containing 3 (NLRP3) inflammasome is a multiprotein complex that induces caspase‐1 activation and the downstream substrates involved with the processing and secretion of the pro‐inflammatory cytokines interleukin‐1β (IL‐1β) and IL‐18 and… read more here.
Keywords: plants bioactive; inflammasome activation; natural products; medicinal plants ... See more keywords
Assessing NLRP3 Inflammasome Activation by Nanoparticles.
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DOI: 10.1007/978-1-4939-7352-1_12
Abstract: NLRP3 inflammasome activation is one of the initial steps in an inflammatory cascade against pathogen/danger-associated molecular patterns (PAMPs/DAMPs), such as those arising from environmental toxins or nanoparticles, and is essential for innate immune response. NLRP3… read more here.
Keywords: inflammasome activation; assessing nlrp3; activation; nlrp3 inflammasome ... See more keywords
Methods to Study Cell Swelling-Induced Inflammasome Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_12
Abstract: Cells present ancestral conserved mechanisms to maintain their volume in response to alterations in environmental osmolarity. Changes in environmental osmolarities are therefore conserved as primitive stress signals. Innate immune cells, such as macrophages, express receptors… read more here.
Keywords: methods study; nlrp3 inflammasome; inflammasome activation; cell swelling ... See more keywords