Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.08.005
Abstract: Inflammatory responses have a pivotal role in the development of diabetic nephropathy (DN). The nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is a newly recognized and potent inflammatory mediator that induces inflammatory responses in… read more here.
Keywords: antidiabetic drugs; drugs nlrp3; inflammasome activity; effects antidiabetic ... See more keywords
Metabolites that activate the inflammasome in nascent metabolic syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2020.107836
Abstract: BACKGROUND Metabolic Syndrome (MetS) is a cardio-metabolic cluster that increases the risk of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). Whilst it affects 35% of the American adult population, its pathogenesis remains… read more here.
Keywords: nascent mets; inflammasome activity; metabolic syndrome; nlrp3 inflammasome ... See more keywords
Inhibition of NLRP3 inflammasome activity by MCC950 leads to exacerbation of Sjӧgren's syndrome pathologies in non‐obese diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13605
Abstract: Sjӧgren's syndrome (SS) is an autoimmune inflammatory disease characterized by chronic inflammation and dysfunction of exocrine glands and causes dry mouth, dry eyes and various systemic health problems. The objective of this study is to… read more here.
Keywords: non obese; disease; mcc950; inflammasome activity ... See more keywords
Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004832
Abstract: Background Compared with the precise targeting of drug-resistant mutant cancer cells, strategies for eliminating non-genetic adaptation-mediated resistance are limited. The pros and cons of the existence of inflammasomes in cancer have been reported. Nevertheless, the… read more here.
Keywords: snail; resistance; inflammasome activity; tumor ... See more keywords
Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS
Sign Up to like & getrecommendations! Published in 2021 at "Journal of International Medical Research"
DOI: 10.1177/0300060520981259
Abstract: Objective To explore the role of lipoxin A4 (LXA4) on inflammasome and inflammatory activity in macrophages activated by Porphyromonas gingivalis lipopolysaccharide (PgLPS) one of the major causative agents of chronic periodontitis. Methods The mouse macrophage… read more here.
Keywords: lipoxin promotes; inflammation; macrophage; inflammasome activity ... See more keywords
SGLT2 Inhibitors Suppress NLRP3 Inflammasome Activity via Changes in Ketones and Insulin in Type 2 Diabetes and Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-164-or
Abstract: SGLT2 inhibitors significantly reduce cardiovascular events in humans with T2D; however, the underlying mechanism remains unclear. Activation of NLRP3 inflammasome and subsequent IL-1β release induces atherosclerosis and heart failure. Recently, it was revealed that ketone… read more here.
Keywords: sglt2 inhibitors; sglt2 inhibitor; inflammasome activity; activation ... See more keywords
Dysregulated inflammasome activity in intestinal inflammation – Insights from patients with very early onset IBD
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1027289
Abstract: Inflammatory bowel disease (IBD) is a multifactorial disorder triggered by imbalances of the microbiome and immune dysregulations in genetically susceptible individuals. Several mouse and human studies have demonstrated that multimeric inflammasomes are critical regulators of… read more here.
Keywords: ibd; early onset; veo ibd; inflammasome activity ... See more keywords