Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.07.011
Abstract: Activation of inflammasome complexes during spinal cord injury (SCI) lead to conversion of pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interleukin-18 (IL-18) to their active form to initiates the neuroinflammation. Mesenchymal stem cells (MSCs) showed anti-inflammatory properties… read more here.
Keywords: stem cells; activity; inflammasome complexes; spinal cord ... See more keywords
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2024.2366872
Abstract: ABSTRACT Introduction Inflammasome complexes, especially NLRP3, have gained great attention as a potential therapeutic target in mood disorders. NLRP3 triggers a caspase 1-dependent release of the inflammatory cytokines IL-1β and IL-18, and seems to interact… read more here.
Keywords: mood disorders; inflammasome complexes; mood; nlrp3 inflammasome ... See more keywords
Emerging mechanisms and functions of inflammasome complexes in teleost fish
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1065181
Abstract: Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death. Inflammasome components have been identified… read more here.
Keywords: inflammasome complexes; functions inflammasome; teleost fish; emerging mechanisms ... See more keywords