A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201905977
Abstract: Refractory periapical periodontitis, which is a persistent infection after root canal treatment, still has no effective treatment. Its most common pathogen is Enterococcus faecalis. Here, the precursor of phytosteroids, dioscin, is introduced to fight against… read more here.
Keywords: dioscin; inflammasome inhibitor; enterococcus faecalis; nlrp3 inflammasome ... See more keywords
Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00124
Abstract: In our efforts to develop novel small-molecule inhibitors for the NOD-like receptor family pyrin-domain-containing 3 (NLRP3) inflammasome as potential disease-modifying agents to treat neurological disorders including multiple sclerosis (MS), a hydroxyl sulfonamide analogue JC-171 has… read more here.
Keywords: hydroxyl sulfonamide; inflammasome inhibitor; sulfonamide analogue; multiple sclerosis ... See more keywords