The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
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DOI: 10.1016/j.bbrc.2019.11.141
Abstract: BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD-like receptor containing pyrin domain 3… read more here.
Keywords: cdk5; inflammasome parkinson; parkinson disease; nlrp3 inflammasome ... See more keywords