Naringenin facilitates M2 macrophage polarization after myocardial ischemia–reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23774
Abstract: Myocardial ischemia–reperfusion injury (MIRI) remains an unsolved puzzle in medical circles. Naringenin (NAR) is a flavonoid with cardioprotective potential. The purpose of this article was to discuss the protective mechanism of NAR in MIRI by… read more here.
Keywords: macrophage polarization; inflammasome pathway; nuclear translocation; polarization ... See more keywords
Possible protective effect of resolvin D1 on inflammation in atrial fibrillation: involvement of ER stress mediated the NLRP3 inflammasome pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02115-0
Abstract: Atrial fibrillation (AF) is the most common type of cardiac rhythm disturbance. At the cellular level, excessive ROS generation during AF is associated with ER stress, which induces an inflammatory response by activating the unfolded… read more here.
Keywords: atrial fibrillation; stress; pathway; nlrp3 inflammasome ... See more keywords
Connexin43 hemichannel block inhibits NLRP3 inflammasome activation in a human retinal explant model of diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108384
Abstract: Diabetic retinopathy (DR), the most common ocular complication associated with diabetes, is a chronic vascular and inflammatory disease that leads to vision loss. The inflammasome pathway, a key part of the innate immune system, is… read more here.
Keywords: nlrp3 inflammasome; model; inflammasome pathway; connexin43 hemichannel ... See more keywords
Interleukin-17 induces pyroptosis in osteoblasts through the NLRP3 inflammasome pathway in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107781
Abstract: OBJECTIVE Interleukin-17 (lL-17), a pro-inflammatory cytokine produced by Th17 cells, is also considered to play an important role in bone metabolism, but the exact mechanism of bone destruction remains unclear. In this study, we explored… read more here.
Keywords: pyroptosis; pyroptosis osteoblasts; nlrp3 inflammasome; inflammasome pathway ... See more keywords
Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway
Sign Up to like & getrecommendations! Published in 2020 at "Respiratory Research"
DOI: 10.1186/s12931-020-01403-2
Abstract: Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal model, alveolar simplification and pro-inflammatory cells infiltration are the main… read more here.
Keywords: caffeine; mice; injury; lung injury ... See more keywords
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1214-5
Abstract: BackgroundInterleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the vicious cycle of inflammation by inducing the expression of various other pro-inflammatory cytokines along with its own production.… read more here.
Keywords: endogenous production; production; activated microglia; nlrp3 inflammasome ... See more keywords
Spotlight on the NLRP3 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s141220
Abstract: Inflammation is triggered by a repertoire of receptors detecting infections and damages. Some of these receptors directly bind microbial ligands, while others recognize endogenous molecules exposed under stress conditions, including infections. Most of these receptors… read more here.
Keywords: inflammation; spotlight nlrp3; activation; nlrp3 inflammasome ... See more keywords
Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-κB/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1120254
Abstract: Lycopene (LY) belongs to carotenoids and is abundant in red fruits and vegetables. Several previous studies suggested that LY is beneficial for ameliorating non-alcoholic fatty liver disease (NAFLD), while the potential mechanisms are unclear. The… read more here.
Keywords: hffd group; inflammasome pathway; hepatic nlrp3; group ... See more keywords
Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.842313
Abstract: Pyroptosis is a highly specific type of inflammatory programmed cell death that is mediated by Gasdermine (GSDM). It is characterized by inflammasome activation, caspase activation, and cell membrane pore formation. Diabetic cardiomyopathy (DCM) is one… read more here.
Keywords: inflammasome pathway; pyroptosis; related inflammasome; pyroptosis related ... See more keywords
Daucosterol Alleviates Alcohol−Induced Hepatic Injury and Inflammation through P38/NF−κB/NLRP3 Inflammasome Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15010223
Abstract: Alcoholic liver disease (ALD) is caused by chronic excessive alcohol consumption, which leads to inflammation, oxidative stress, lipid accumulation, liver fibrosis/cirrhosis, and even liver cancer. However, there are currently no effective drugs for ALD. Herein,… read more here.
Keywords: inflammation; inflammasome pathway; daucosterol alleviates; injury ... See more keywords