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   Articles with "inflammasome signaling" as a keyword



PARP inhibition by olaparib alleviates chronic asthma‐associated remodeling features via modulating inflammasome signaling in mice

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recommendations! Published in 2019 at "IUBMB Life"

DOI: 10.1002/iub.2048

Abstract: Despite the reported role of poly(ADP‐ribose) polymerase (PARP) in asthma inflammation, its contribution during remodeling is not clearly known. The main aim of the current investigation was to examine the potential of olaparib, a pharmacological… read more here.

Keywords: olaparib; via modulating; inflammasome signaling; chronic asthma ... See more keywords

Neutrophil‐derived extracellular vesicles promote feed‐forward inflammasome signaling in cystic fibrosis airways

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recommendations! Published in 2022 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3ab0321-149r

Abstract: Cystic fibrosis (CF) airways feature high extracellular levels of the IL‐1 family of proinflammatory mediators. These mediators are cleavage products of caspase‐1, the final protease in the inflammasome cascade. Due to the proven chronic presence… read more here.

Keywords: extracellular vesicles; neutrophil derived; inflammasome signaling; feed forward ... See more keywords

Morin Protects LPS-Induced Mastitis via Inhibiting NLRP3 Inflammasome and NF-κB Signaling Pathways

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recommendations! Published in 2020 at "Inflammation"

DOI: 10.1007/s10753-020-01208-x

Abstract: Mastitis is one of the most common diseases that both affects human and animals. Morin is derived from the member of Moraceae family, which has been used in the treatment of many inflammatory diseases. The… read more here.

Keywords: lps induced; mastitis; inflammasome signaling; morin ... See more keywords

TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways

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recommendations! Published in 2019 at "Hepatology International"

DOI: 10.1007/s12072-019-09997-6

Abstract: Background This study aimed to investigate the roles and mechanisms of tenofovir alafenamide fumarate (TAF)/tenofovir disoproxil fumarate (TDF) in treating liver fibrosis. Methods The effects of TAF/TDF on carbon tetrachloride (CCl 4 )-induced liver fibrosis… read more here.

Keywords: signaling pathways; liver fibrosis; inflammasome signaling; nlrp3 inflammasome ... See more keywords
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Structural and mechanistic elucidation of inflammasome signaling by cryo-EM.

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recommendations! Published in 2019 at "Current opinion in structural biology"

DOI: 10.1016/j.sbi.2019.03.033

Abstract: The innate immune system forms an evolutionarily ancient line of defense against invading pathogens and endogenous danger signals. Within certain cells of innate immunity, including epithelial cells and macrophages, intricate molecular machineries named inflammasomes sense… read more here.

Keywords: elucidation inflammasome; mechanistic elucidation; inflammasome signaling; structural mechanistic ... See more keywords
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Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling.

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recommendations! Published in 2021 at "Toxicology letters"

DOI: 10.1016/j.toxlet.2021.10.011

Abstract: Aurantio-obtusin (AO) is a major anthraquinone (AQ) compound derived from Cassiae semen (CS). Although pharmacological studies have shown that the CS extracts can serve as effective agents in preclinical and clinical practice, AQ-induced hepatotoxicity in… read more here.

Keywords: induced hepatotoxicity; induces hepatotoxicity; inflammasome signaling; aurantio obtusin ... See more keywords

Apium graveolens L. alleviates acute lung injury in human A-549 cells by reducing NF-κB and NLRP3 inflammasome signaling

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recommendations! Published in 2024 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2024.2433994

Abstract: Abstract Background Apium graveolens L. (celery) is a dietary vegetable with anti-inflammatory properties. It has the potential to treat acute lung injury (ALI) caused by COVID-19 or other diseases. Objective To investigate the effects of… read more here.

Keywords: inflammasome signaling; lung injury; nlrp3 inflammasome; acute lung ... See more keywords

NOD-like receptor X1 promotes autophagy and inactivates NLR family pyrin domain containing 3 inflammasome signaling by binding autophagy-related gene 5 to alleviate cerebral ischemia/reperfusion-induced neuronal injury.

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recommendations! Published in 2024 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlae129

Abstract: Ischemic strokes pose serious risks to human health. We aimed to elucidate the function of NOD-like receptor X1 (NLRX1) in a rat middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury (CIRI) model and in an… read more here.

Keywords: like receptor; nod like; cerebral ischemia; inflammasome signaling ... See more keywords

Inflammasome Signaling and Impaired Vascular Health in Psoriasis

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recommendations! Published in 2019 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.118.312246

Abstract: Objective— Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results— Twenty patients… read more here.

Keywords: health; bgr; psoriasis; disease ... See more keywords

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

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recommendations! Published in 2018 at "Circulation"

DOI: 10.1161/circulationaha.118.035202

Abstract: Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome mediates caspase-1 activation and interleukin-1&bgr; release in immune cells but is not known… read more here.

Keywords: atrial fibrillation; inflammasome signaling; mice; activation ... See more keywords

Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells

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recommendations! Published in 2021 at "Journal of Inflammation Research"

DOI: 10.2147/jir.s318812

Abstract: Introduction The extend to the clinical benefit of radiation therapy is the inability to eliminate only cancer cells and destroy normal cells such as microvascular endothelial in the vascular niche and turn induced-inflammasome signaling and… read more here.

Keywords: radiation; gamma radiation; pyroptosis; endothelial cells ... See more keywords