PARP inhibition by olaparib alleviates chronic asthma‐associated remodeling features via modulating inflammasome signaling in mice
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2048
Abstract: Despite the reported role of poly(ADP‐ribose) polymerase (PARP) in asthma inflammation, its contribution during remodeling is not clearly known. The main aim of the current investigation was to examine the potential of olaparib, a pharmacological… read more here.
Keywords: olaparib; via modulating; inflammasome signaling; chronic asthma ... See more keywords
Neutrophil‐derived extracellular vesicles promote feed‐forward inflammasome signaling in cystic fibrosis airways
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0321-149r
Abstract: Cystic fibrosis (CF) airways feature high extracellular levels of the IL‐1 family of proinflammatory mediators. These mediators are cleavage products of caspase‐1, the final protease in the inflammasome cascade. Due to the proven chronic presence… read more here.
Keywords: extracellular vesicles; neutrophil derived; inflammasome signaling; feed forward ... See more keywords
Morin Protects LPS-Induced Mastitis via Inhibiting NLRP3 Inflammasome and NF-κB Signaling Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01208-x
Abstract: Mastitis is one of the most common diseases that both affects human and animals. Morin is derived from the member of Moraceae family, which has been used in the treatment of many inflammatory diseases. The… read more here.
Keywords: lps induced; mastitis; inflammasome signaling; morin ... See more keywords
TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology International"
DOI: 10.1007/s12072-019-09997-6
Abstract: Background This study aimed to investigate the roles and mechanisms of tenofovir alafenamide fumarate (TAF)/tenofovir disoproxil fumarate (TDF) in treating liver fibrosis. Methods The effects of TAF/TDF on carbon tetrachloride (CCl 4 )-induced liver fibrosis… read more here.
Keywords: signaling pathways; liver fibrosis; inflammasome signaling; nlrp3 inflammasome ... See more keywords
Structural and mechanistic elucidation of inflammasome signaling by cryo-EM.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.03.033
Abstract: The innate immune system forms an evolutionarily ancient line of defense against invading pathogens and endogenous danger signals. Within certain cells of innate immunity, including epithelial cells and macrophages, intricate molecular machineries named inflammasomes sense… read more here.
Keywords: elucidation inflammasome; mechanistic elucidation; inflammasome signaling; structural mechanistic ... See more keywords
Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.10.011
Abstract: Aurantio-obtusin (AO) is a major anthraquinone (AQ) compound derived from Cassiae semen (CS). Although pharmacological studies have shown that the CS extracts can serve as effective agents in preclinical and clinical practice, AQ-induced hepatotoxicity in… read more here.
Keywords: induced hepatotoxicity; induces hepatotoxicity; inflammasome signaling; aurantio obtusin ... See more keywords
Inflammasome Signaling and Impaired Vascular Health in Psoriasis
Sign Up to like & getrecommendations! Published in 2019 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.118.312246
Abstract: Objective— Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results— Twenty patients… read more here.
Keywords: health; bgr; psoriasis; disease ... See more keywords
Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation
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DOI: 10.1161/circulationaha.118.035202
Abstract: Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome mediates caspase-1 activation and interleukin-1&bgr; release in immune cells but is not known… read more here.
Keywords: atrial fibrillation; inflammasome signaling; mice; activation ... See more keywords
Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s318812
Abstract: Introduction The extend to the clinical benefit of radiation therapy is the inability to eliminate only cancer cells and destroy normal cells such as microvascular endothelial in the vascular niche and turn induced-inflammasome signaling and… read more here.
Keywords: radiation; gamma radiation; pyroptosis; endothelial cells ... See more keywords
The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s390310
Abstract: Abstract Diabetes is a significant risk factor for arrhythmias. However, the pathophysiology of diabetes-related arrhythmias still needs to be elucidated, presumably associated with structural and electrical remodeling. There is growing evidence that inflammation and arrhythmias… read more here.
Keywords: role; related arrhythmias; inflammasome signaling; diabetes related ... See more keywords
Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.691445
Abstract: Aeromonas sobria, a common conditional pathogenic bacteria, is widely distributed in the environment and causes gastroenteritis in humans or septicemia in fish. Of all Aeromonas species, A. sobria is the most frequently isolated from human… read more here.
Keywords: signaling pathways; production; activating nlrp3; inflammasome signaling ... See more keywords