Exosomes and MicroRNA‐223 at the Intersection of Inflammation and Fibrosis in NAFLD
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31805
Abstract: Nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH) are the most common causes of liver disease. Progression of nonalcoholic fatty liver disease (NAFLD) to NASH is mediated by multiple signals that include activation of inflammatory cells,… read more here.
Keywords: inflammation fibrosis; intersection inflammation; exosomes microrna; fibrosis nafld ... See more keywords
NOD‐like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32320
Abstract: The NOD‐like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we… read more here.
Keywords: nod like; like receptor; inflammation fibrosis; receptor protein ... See more keywords
Circ_0123996 promotes the proliferation, inflammation, and fibrosis of mesangial cells by sponging miR‐203a‐3p to upregulate SOX6 in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23139
Abstract: Circular RNA has been reported to participate in human diseases including diabetic nephropathy (DN). However, the role and mechanism of circ_0123996 in DN need to be further explored. Relative expression levels of circ_0123996, microRNA (miR)‐203a‐3p,… read more here.
Keywords: mir 203a; proliferation inflammation; inflammation fibrosis; circ 0123996 ... See more keywords
miR‐15a‐5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27660
Abstract: Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum… read more here.
Keywords: inflammation fibrosis; fibrosis peritoneal; mir 15a; mesothelial cells ... See more keywords
The effector cells and cellular mediators of immune system involved in cardiac inflammation and fibrosis after myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29732
Abstract: The cardiac repair after myocardial infarction (MI) involves two phases, namely, inflammatory response and proliferative response. The former is an inflammatory reaction, evoked by different kinds of pro‐inflammatory leukocytes and molecules stimulated by myocardial necrosis,… read more here.
Keywords: inflammation fibrosis; fibrosis; myocardial infarction; inflammation ... See more keywords
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2364-z
Abstract: PurposeHepatocellular carcinoma (HCC) cases are closely associated with chronic inflammation and fibrosis which is known as hepatic inflammation-fibrosis-cancer (IFC) axis. The aim of this study is to elucidate the development characteristics of the rat HCC… read more here.
Keywords: inflammation fibrosis; week; fibrosis; group ... See more keywords
Label-free Raman spectroscopy characterizes signatures of inflammation and fibrosis in the silicosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.107
Abstract: Silicosis is an occupational disease that seriously damages the life and health of miners. Herein, we constructed a mouse model of silicosis and used label-free confocal Raman spectroscopy to analyze the biomolecular variations in lung… read more here.
Keywords: raman spectroscopy; label free; silicosis; spectroscopy ... See more keywords
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.03.047
Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic bronchitis, small airway obstruction, and emphysema that represents a leading cause of death worldwide. While inflammation, fibrosis, mucus hypersecretion, and metaplastic epithelial lesions are… read more here.
Keywords: inflammation fibrosis; regenerative metaplastic; clones copd; inflammation ... See more keywords
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Discovery"
DOI: 10.1038/celldisc.2017.23
Abstract: Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events… read more here.
Keywords: inflammation fibrosis; experimental pneumoconiosis; pneumoconiosis; fibrosis experimental ... See more keywords
Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/s41366-018-0005-5
Abstract: Background/Objectives:Obesity is related to a dynamic extracellular matrix (ECM) remodeling, which involves the synthesis and degradation of different proteins, such as tenascin C (TNC) in the adipose tissue (AT). Given the functional relationship between leptin… read more here.
Keywords: inflammation fibrosis; ecm remodeling; leptin; inflammation ... See more keywords
Succinate receptor mediates intestinal inflammation and fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0087-3
Abstract: Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. We analyze SUCNR1 expression in the intestine of Crohn's disease patients and… read more here.
Keywords: inflammation fibrosis; sucnr1 expression; intestinal inflammation; succinate ... See more keywords