Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
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DOI: 10.1093/brain/awaa246
Abstract: Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA also in patients with Parkin/PINK1… read more here.
Keywords: mitochondrial damage; inflammation highlights; highlights biomarkers; inflammation ... See more keywords