Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3‐L1 preadipocytes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13516
Abstract: Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and… read more here.
Keywords: 3t3 preadipocytes; insulin signaling; receptor; gpr50 ... See more keywords
Inflammation and insulin resistance: New targets encourage new thinking
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700036
Abstract: Galectin‐3 and LTB4 are pro‐inflammatory molecules recently shown to directly cause insulin resistance in mouse and human cells. They are highly expressed in the obese state, and can be targeted both genetically and pharmacologically to… read more here.
Keywords: insulin; insulin resistance; inflammation insulin; new targets ... See more keywords
Anthocyanins ameliorate palmitate‐induced inflammation and insulin resistance in 3T3‐L1 adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6379
Abstract: Increased adiposity has been associated with adipose tissue low‐grade inflammation leading to insulin resistance. Adipocyte differentiation inhibitors are expected to be effective in preventing obesity and related diseases. Anthocyanins (ACNs) are associated to enhanced adipocyte… read more here.
Keywords: inflammation insulin; insulin; resistance 3t3; insulin resistance ... See more keywords
Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes
Sign Up to like & getrecommendations! Published in 2021 at "Current Diabetes Reports"
DOI: 10.1007/s11892-021-01430-3
Abstract: Diabetes mellitus can be categorized into two major variants, type 1 and type 2. A number of traits such as clinical phenotype, age at disease onset, genetic background, and underlying pathogenesis distinguish the two forms.… read more here.
Keywords: resistance hallmarks; resistance; insulin resistance; autoimmune inflammation ... See more keywords
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.01.009
Abstract: It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. How the interface of immunity and metabolism impinges upon the diabetes… read more here.
Keywords: inflammation insulin; aging associated; inflammation; insulin resistance ... See more keywords
Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis.
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2017.07.013
Abstract: AIM The imbalance between proapoptotic granzyme B (GZB)/perforin (PRF) system and proteinase inhibitor-9 (PI-9; serpinB9); the only known inhibitor of human GZB, has been demonstrated in atherosclerosis. However, their role in atherosclerosis with the impact… read more here.
Keywords: insulin; insulin resistance; peripheral leucocytes; gzb ... See more keywords
Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73347-y
Abstract: Adipose tissue (AT) associated cytokines are involved in the development of chronic low-grade inflammation in obese individuals. IL-2, a pleiotropic cytokine, contributes to immune alterations during inflammation. However, the interaction between AT-IL-2 and other inflammatory… read more here.
Keywords: inflammation; expression; insulin resistance; inflammation insulin ... See more keywords
Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine
Sign Up to like & getrecommendations! Published in 2018 at "Adipocyte"
DOI: 10.1080/21623945.2017.1405191
Abstract: ABSTRACT In rodents, experimentally-induced ovarian hormone deficiency increases adiposity and adipose tissue (AT) inflammation, which is thought to contribute to insulin resistance and increased cardiovascular disease risk. However, whether this occurs in a translationally-relevant large… read more here.
Keywords: swine; inflammation insulin; inflammation; insulin resistance ... See more keywords
A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.905266
Abstract: Background Systemic inflammation and insulin resistance (IR) are closely related in patients with cancer. However, there is no relevant indicator that combines inflammation and IR to predict patient prognosis. Therefore, this study aimed to develop… read more here.
Keywords: patients cancer; cancer; survival; inflammation insulin ... See more keywords
Swimming Suppresses Cognitive Decline of HFD-Induced Obese Mice through Reversing Hippocampal Inflammation, Insulin Resistance, and BDNF Level
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14122432
Abstract: Obesity is an important public health problem nowadays. Long-term obesity can trigger a series of chronic diseases and impair the learning and memory function of the brain. Current studies show that scientific exercise can effectively… read more here.
Keywords: hfd; obese mice; cognitive capacity; obesity ... See more keywords