Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model.
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DOI: 10.1016/j.cbi.2019.108933
Abstract: Irinotecan is a chemotherapeutic drug used in the treatment of advanced colorectal cancer and elevated blood concentrations of its active metabolite, SN-38 leads to increased gastrointestinal (GI) toxicity and diarrhea in patients. In this study,… read more here.
Keywords: best fit; inflammation; inflammation irinotecan; effects inflammation ... See more keywords