A PROTEOMIC ANALYSIS OF GSD-1a IN MOUSE LIVERS: EVIDENCE FOR METABOLIC REPROGRAMMING, INFLAMMATION AND MACROPHAGE POLARIZATION.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00309
Abstract: Glycogen storage disease type 1a (GSD-1a) is a rare genetic disease caused by mutations in the catalytic subunit of the enzyme glucose-6-phosphatase-alpha (G6Pase-α). The majority of patients develop long-term complications including renal failure and hepatocellular… read more here.
Keywords: metabolic reprogramming; macrophage polarization; liver; mice ... See more keywords
Ginkgolic acid promotes inflammation and macrophage apoptosis via SUMOylation and NF-κB pathways in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1108882
Abstract: Background Excessive inflammation and increased apoptosis of macrophages contribute to organ damage and poor prognosis of sepsis. Ginkgolic acid (GA) is a natural constituent extracted from the leaves of Ginkgo biloba, that can regulate inflammation… read more here.
Keywords: apoptosis; sumoylation; inflammation macrophage; promotes inflammation ... See more keywords