Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00447-7
Abstract: Galectin 3-binding protein (LGALS3BP, also known as 90K) is a multifunctional glycoprotein involved in immunity and cancer. However, its precise role in colon inflammation and tumorigenesis remains unclear. Here, we showed that Lgals3bp −/− mice… read more here.
Keywords: lgals3bp mice; tumorigenesis; inflammation tumorigenesis; colon inflammation ... See more keywords
Platelets couple inflammation to tumorigenesis, a bridge too far
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13967
Abstract: Platelets were first implicated in the pathogenesis of cancer and inflammatory pathologies decades ago, but an understanding of the mechanisms coupling platelet function to cancer progression is still a work in progress. In their paper,… read more here.
Keywords: tumorigenesis; inflammation tumorigenesis; tumorigenesis bridge; couple inflammation ... See more keywords
Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.862237
Abstract: Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we… read more here.
Keywords: tumorigenesis; vimentin; mouse; inflammation tumorigenesis ... See more keywords
Intestinal Gasdermins for regulation of inflammation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1052111
Abstract: Gasdermins (GSDMs) protein family express in intestinal epithelial cells or lamina propria immune cells, and play a nonnegligible function during gut homeostasis. With the gradually in-depth investigation of GSDMs protein family, the proteases that cleave… read more here.
Keywords: inflammation; pyroptosis; intestinal gasdermins; gasdermins regulation ... See more keywords
Tumor progression locus 2 (TPL2) in tumor-promoting Inflammation, Tumorigenesis and Tumor Immunity
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.45848
Abstract: Over the years, tumor progression locus 2 (TPL2) has been identified as an essential modulator of immune responses that conveys inflammatory signals to downstream effectors, subsequently modulating the generation and function of inflammatory cells. TPL2… read more here.
Keywords: tumor progression; inflammation tumorigenesis; inflammation; tumor ... See more keywords