Metal‐Organic Frameworks for the Therapy of Inflammatory Diseases
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DOI: 10.1002/adhm.202404334
Abstract: Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead to various inflammatory diseases such as rheumatoid arthritis (RA),… read more here.
Keywords: therapy inflammatory; inflammatory; organic frameworks; drug ... See more keywords
A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response.
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DOI: 10.1002/adma.201805209
Abstract: Immunology is the next frontier of nano/biomaterial science research, with the immune system determining the degree of tissue repair. However, the complexity of the inflammatory response represents a significant challenge that is essential to understand… read more here.
Keywords: anti inflammatory; response; inflammatory; programmed anti ... See more keywords
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury.
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DOI: 10.1002/adma.202210579
Abstract: Acute respiratory distress syndrome (ARDS) represents a significant burden to the health care system, with approximately 200,000 cases diagnosed annually in the US. ARDS patients suffer from severe refractory hypoxemia, alveolar-capillary barrier dysfunction, impaired surfactant… read more here.
Keywords: dermal fibroblasts; inflammation; engineered extracellular; lung ... See more keywords
Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
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DOI: 10.1002/advs.202104372
Abstract: Recently, first insights into the regulation and the role of the RNA‐binding protein IMP2 in macrophage activation have been published by Wang et al. This study addresses differences in the regulation of IMP2 between the… read more here.
Keywords: inflammatory; reader igf2bp2; igf2bp2 regulates; m6a reader ... See more keywords
Inflammation‐Controlled Anti‐Inflammatory Hydrogels
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DOI: 10.1002/advs.202206412
Abstract: While autoregulative adaptation is a common feature of living tissues, only a few feedback‐controlled adaptive biomaterials are available so far. This paper herein reports a new polymer hydrogel platform designed to release anti‐inflammatory molecules in… read more here.
Keywords: controlled anti; anti inflammatory; inflammatory; inflammatory hydrogels ... See more keywords
All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity
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DOI: 10.1002/advs.202206771
Abstract: Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty… read more here.
Keywords: diabetic wound; inflammatory; wound healing; macrophage heterogeneity ... See more keywords
Remodeling of the Intra‐Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein‐Based Conduit
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DOI: 10.1002/advs.202302988
Abstract: Peripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common treatment for PNI, but the prognosis of NGC treatment is unsatisfactory due to 1) neuromechanical unmatching… read more here.
Keywords: nerve; intra conduit; conduit; inflammatory ... See more keywords
Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses
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DOI: 10.1002/advs.202307201
Abstract: Macrophages regulate essential aspects of innate immunity against pathogens. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. The liver X receptors (LXRα, LXRβ) are ligand‐dependent nuclear… read more here.
Keywords: secondary inflammatory; reprogramming lxr; gene expression; inflammatory ... See more keywords
Macrophage‐Mimicking Cellular Nanoparticles Scavenge Proinflammatory Cytokines in Specimens of Patients with Inflammatory Disorders
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DOI: 10.1002/advs.202401423
Abstract: Effectively neutralizing inflammatory cytokines is crucial for managing a variety of inflammatory disorders. Current techniques that target only a subset of cytokines often fall short due to the intricate nature of redundant and compensatory cytokine… read more here.
Keywords: mimicking cellular; macrophage mimicking; inflammatory cytokines; inflammatory ... See more keywords
Nanoenzymes‐Integrated and Microenvironment Self‐Adaptive Hydrogel for the Healing of Burn Injury and Post‐Burn Depression
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DOI: 10.1002/advs.202413032
Abstract: Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients’ quality of life. The primary function of traditional burn… read more here.
Keywords: burn; burn depression; inflammatory; depression ... See more keywords
Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses.
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DOI: 10.1002/advs.202502395
Abstract: Macrophage plasticity, critical for immune response, is often dysregulated in various infectious and inflammatory diseases. While ion channels have been implicated in immune cell modulation, how they influence macrophage polarization remains poorly understood. Here, it… read more here.
Keywords: chp1 camk4; calhm6; macrophage polarization; inflammatory ... See more keywords