Inflammatory activation of microglia by Staphylococcus aureus caused phenotypic alterations and affected glioblastoma growth
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3396
Abstract: As the most common type of tumour in brain, glioma has a high rate of morbidity and mortality and easily penetrates the surrounding normal brain parenchyma. The immunosuppressive microenvironment, which is similar to that in… read more here.
Keywords: microglia activated; staphylococcus aureus; inflammatory activation; glioma ... See more keywords
Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23558
Abstract: Accumulating evidence indicates that neuroinflammation contributes to the pathogenesis and exacerbation of neurodegenerative disorders, such as Alzheimer's disease (AD). Sphingosine‐1‐phosphate (S1P) is a pleiotropic bioactive lipid that regulates many pathophysiological processes including inflammation. We present… read more here.
Keywords: promotes microglia; microglia pro; inflammatory activation; spns2 ... See more keywords
β4GalT1 Mediates PPARγ N-Glycosylation to Attenuate Microglia Inflammatory Activation
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0789-4
Abstract: The inflammatory activation of microglia has double-edged effects in central nervous system (CNS) diseases. The ligand-activated transcriptional factor peroxisome proliferator-activated receptor γ (PPARγ) inhibits the inflammatory response. β-1,4-Galactosyltransferase Ι (β1, 4GalT1) mediates N-glycosylation. In this… read more here.
Keywords: ppar; 4galt1 mediates; inflammatory activation; glycosylation ... See more keywords
Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105743
Abstract: Macrophages are immune system cells that respond to various pathogenic insults. The recognition of antigens is performed through receptors such as TLR4 and RAGE, which recognize pathogen-associated patterns (PAMPs), including lipopolysaccharide (LPS) from Gram-negative bacteria.… read more here.
Keywords: inflammatory activation; lps induced; activation; activation raw ... See more keywords
Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium.
Sign Up to like & getrecommendations! Published in 2021 at "Tissue barriers"
DOI: 10.1080/21688370.2021.1956284
Abstract: BACKGROUND Rivaroxaban is one of the direct factor Xa inhibitors. Its function in the inactivated coagulation cascade is unclear. The aim of the study was to assess the effect of rivaroxaban on the endothelial integrity… read more here.
Keywords: inflammatory activation; rivaroxaban; tissue; integrity ... See more keywords
Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a)
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehaa171
Abstract: Abstract Aims Elevated lipoprotein(a) [Lp(a)] is strongly associated with an increased cardiovascular disease (CVD) risk. We previously reported that pro-inflammatory activation of circulating monocytes is a potential mechanism by which Lp(a) mediates CVD. Since potent… read more here.
Keywords: inflammatory activation; patients elevated; treatment; circulating monocytes ... See more keywords
Maresin 1 attenuates pro‐inflammatory activation induced by β‐amyloid and stimulates its uptake
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16098
Abstract: Alzheimer's disease (AD) is the most common dementia, characterized by pathological accumulation of β‐amyloid (Aβ) and hyperphosphorylation of tau protein, together with a damaging chronic inflammation. The lack of effective treatments urgently warrants new therapeutic… read more here.
Keywords: inflammatory activation; mar1; pro resolving; activation ... See more keywords
Pro‐inflammatory activation of microglia in the brain of patients with sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12502
Abstract: Experimental data suggest that systemic immune activation may create a pro‐inflammatory environment with microglia activation in the central nervous system in the absence of overt inflammation, which in turn may be deleterious in conditions of… read more here.
Keywords: inflammatory activation; activation microglia; activation; microglia brain ... See more keywords
P085 Activated memory T cells produce ligands that cause NF-ΚB-dependent inflammatory activation of the endothelium
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.74
Abstract: Career situation of first and presenting author Student for a master or a PhD. Introduction Endothelial cells (EC) are important contributors to inflammation via expression of inflammatory mediators, including chemokines and adhesion molecules. Production of… read more here.
Keywords: dependent inflammatory; activation; memory cells; inflammatory mediators ... See more keywords
Sinomenine relieves oxygen and glucose deprivation-induced microglial activation via inhibition of the SP1/miRNA-183-5p/IκB-α signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2018.64.10.23
Abstract: Studies have shown that the inflammatory activation of miroglia (MG) and nuclear factor kappa B ( NF-κB ) play a dominant role in inflammatory response. Previous studies have shown that sinomenine, an anti-inflammatory agent extracted… read more here.
Keywords: inflammatory activation; mirna 183; glucose deprivation; oxygen glucose ... See more keywords
Mitochondrial Dynamics and Bioenergetic Alteration During Inflammatory Activation of Astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.614410
Abstract: Mitochondria are essential cellular organelles that act as metabolic centers and signaling platforms and have been identified as an important subcellular target in a broad range of neuropathologies. Studies on the role of mitochondria in… read more here.
Keywords: bioenergetic alteration; dynamics bioenergetic; alteration inflammatory; inflammatory activation ... See more keywords