A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200136
Abstract: In an endeavor to identify potent anti‐inflammatory agents, new thiosemicarbazones (TSCs) incorporated into a diaryl ether framework (2a–2l) were prepared and screened for their in vitro inhibitory effects on cyclooxygenases (COXs). 4‐[4‐(Piperidin‐1‐ylsulfonyl)phenyl]‐1‐[4‐(4‐cyanophenoxy)benzylidene]thiosemicarbazide (2c) was the… read more here.
Keywords: series thiosemicarbazone; cox; inflammatory agents; anti inflammatory ... See more keywords
Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105663
Abstract: Keeping in view the involvement of inflammation in the pathogenesis of several diseases including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein, we review the processes for the initiation of inflammation and the treatment measures.… read more here.
Keywords: inflammatory agents; biochemistry; inflammation biochemistry; anti inflammatory ... See more keywords
Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.035
Abstract: Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two… read more here.
Keywords: anti inflammatory; pyridazinone derivatives; derivatives potential; biological evaluation ... See more keywords
Safer anti‐inflammatory therapy through dual COX‐2/5‐LOX inhibitors: A structure‐based approach
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.06.003
Abstract: &NA; Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings. Chronic inflammation is associated with the pathogenesis and progression of cancer,… read more here.
Keywords: anti inflammatory; safer anti; inflammatory agents; cox ... See more keywords
Design, synthesis, biological evaluation, and molecular docking study on triazine based derivatives as anti-inflammatory agents
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130760
Abstract: Abstract In an attempt to develop new anti-inflammatory agents, design, synthesis, pharmacological activities, and docking study of two groups of triazine-based derivatives were reported. Nine compounds (5a-5d and 10a-10e) consisting of triazine, vanillin, and phenylpyrazole… read more here.
Keywords: inflammatory agents; design synthesis; anti inflammatory; triazine based ... See more keywords
Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2090546
Abstract: Abstract Current medical approaches to control the Covid-19 pandemic are either to directly target the SARS-CoV-2 via innovate a defined drug and a safe vaccine or indirectly target the medical complications of the virus. One… read more here.
Keywords: pyrrolopyrimidine derivatives; molecular docking; antioxidant anti; inflammatory agents ... See more keywords
Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agents
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2187327
Abstract: Abstract The major labdanes in the oleogum resin of Araucaria heterophylla (Salisb.) Franco, 13-epi-cupressic acid (1) and acetyl-13-epi-cupressic acid (2) were used to prepare seven new (3–9), along with one known (10) derivatives. RAW264.7 cells… read more here.
Keywords: design biological; inflammatory agents; anti inflammatory; cupressic acid ... See more keywords
Synthesis and cytotoxic activity of ethyl ferulate derivatives as potent anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2118739
Abstract: While a range of pharmacological agents are currently used to alleviate inflammation, the clinical administration of many of these anti-inflammatory drugs is associated with high rates of adverse side effects that make them poorly suited… read more here.
Keywords: inflammatory agents; anti inflammatory; ethyl ferulate; inflammatory ... See more keywords
The Utility of Anti-Inflammatory Agents in Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248418778548
Abstract: Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical… read more here.
Keywords: anti inflammatory; medicine; disease; inflammatory agents ... See more keywords
Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis
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DOI: 10.2147/jir.s190007
Abstract: We postulate that the extensive cell and tissue damage inflicted by many infectious, inflammatory and post-inflammatory episodes is an enled result of a synergism among the invading microbial agents, host neutrophils and dead and dying… read more here.
Keywords: inflammatory; pro inflammatory; inflammatory agents; tissue ... See more keywords
Topical Anti-Inflammatory Agents for Non-Infectious Uveitis: Current Treatment and Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s288294
Abstract: Abstract Non-infectious uveitis represents a heterogenous group of immune-mediated ocular diseases, which can be associated with underlying systemic disease. While the initial choice of treatment of non-infectious uveitis depends on a number of factors such… read more here.
Keywords: non infectious; inflammatory agents; anti inflammatory; infectious uveitis ... See more keywords