Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens
Sign Up to like & getrecommendations! Published in 2025 at "Genome Biology"
DOI: 10.1186/s13059-025-03683-7
Abstract: Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging. We perform multiple genome-wide CRISPR interference… read more here.
Keywords: inflammatory aging; aging inflammatory; aging signatures; identification replicative ... See more keywords
Inflammatory aging clock: A cancer clock to characterize the patients’ subtypes and predict the overall survival in glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.925469
Abstract: Background: Many biological clocks related to aging have been linked to the development of cancer. A recent study has identified that the inflammatory aging clock was an excellent indicator to track multiple diseases. However, the… read more here.
Keywords: aging clock; iage; inflammatory aging; clock ... See more keywords
NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2025.1636787
Abstract: Ataxia–telangiectasia (A–T) is a rare, autosomal recessive, multisystem disorder caused by mutations in the Ataxia–Telangiectasia Mutated (ATM) gene and is characterized by a devastating and progressive neurological pathology. The cellular and molecular changes driving the… read more here.
Keywords: inflammatory aging; netsseq reveals; cell; reveals inflammatory ... See more keywords
Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging
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DOI: 10.34133/research.0704
Abstract: Vascular inflammatory aging is strongly associated with multimorbidity, including immunosenescence. Here, bioinformatic analysis indicated elevated expression of the lysozyme (LYZ) gene in age-dependent vascular diseases. Lyz1 deficiency led to vascular inflammatory aging, including damage to… read more here.
Keywords: inflammatory aging; lyz1 mice; gut microbiota; pi3k akt ... See more keywords