Challenges to develop novel anti-inflammatory and analgesic drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1427
Abstract: Chronic inflammatory diseases and persistent pain of different origin represent common medical, social, and economic burden, and their pharmacotherapy is still an unresolved issue. Therefore, there is a great and urgent need to develop anti-inflammatory… read more here.
Keywords: anti inflammatory; challenges develop; develop novel; inflammatory ... See more keywords
Monitoring the release of anti-inflammatory and analgesic pharmaceuticals in the receiving environment
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-06821-4
Abstract: The occurrence of anti-inflammatory and analgesic pharmaceuticals (AIAPs) in the effluents of 16 hospitals, influent and effluent of wastewater treatment plant (WWTP), the contribution and mass load of each hospital to WWTP influent, and the… read more here.
Keywords: anti inflammatory; winter; analgesic pharmaceuticals; summer ... See more keywords
HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114258
Abstract: Combinational utilization of intravenous non-steroidal anti-inflammatory drugs (NSAIDs) with opium analgesic is an effective alternative modality for pain control after surgery. This regimen is known for reducing the risk of addiction induced by opium analgesic.… read more here.
Keywords: inflammatory analgesic; hr1405 safe; analgesic activities; intravenous nsaid ... See more keywords
Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.01.041
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Stem bark of Alnus nitida (Spach) Endl. (family Betulaceae) is used by local communities in northern areas of Pakistan as a remedy for swelling, injuries and pain. However no pharmacological study of this… read more here.
Keywords: anti inflammatory; bark; stem bark; inflammatory analgesic ... See more keywords
Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens Makino by inhibiting COX-2 expression and inflammatory cell infiltration.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113547
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The Chinese traditional medicine of Siegesbeckia pubescens Makino (SM), which has the effect of healing rheumatism and promoting joint health, is often used to treat rheumatoid arthritis and ischemic stroke. AIM OF THE… read more here.
Keywords: anti inflammatory; pubescens makino; siegesbeckia pubescens; active ingredients ... See more keywords
Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb Colocasia gigantea and molecular docking study against COX-II enzyme.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114577
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Consumable herbs play a basic part in sustenance and human health. Traditionally, Colocasia gigantea Hook (Araceae) is used to treat fever, infection, wounds healing, drowsiness, tuberculosis, stomach problems etc. AIM OF THE STUDY:… read more here.
Keywords: anti inflammatory; study; edible herb; inflammatory analgesic ... See more keywords
Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130565
Abstract: Abstract Herein, two novel series of diaryl-1,2,4-triazole hybrid to amide conjugates (5a-e) or urea conjugates (10a-f) have been synthesized followed by in vitro evaluation against cyclo-oxygenase-2/soluble epoxide hydrolase (COX-2/sEH) enzymes using ELISA enzyme assays. In… read more here.
Keywords: diaryl triazole; dual cox; inflammatory analgesic; anti inflammatory ... See more keywords
Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic effect
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1765180
Abstract: Abstract Psoriasis is a chronic autoinflammatory disorder characterized by patches of abnormal skin. For psoriasis management, the application of topical retinoids as Tazarotene is recommended. However, Tazarotene could induce skin irritation limiting its use. Herein,… read more here.
Keywords: anti inflammatory; tazarotene; situ gels; management ... See more keywords
Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1426573
Abstract: Abstract Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities. Molecular docking showed an excellent binding interaction of the synthesised compounds with… read more here.
Keywords: anti inflammatory; analgesic agents; 17c 17i; novel anti ... See more keywords
Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2104274
Abstract: Abstract This study reports the isolation of iridoids and cycloartane glycosides from the aerial parts of Phlomoides labiosa Bunge. Six compounds were isolated and the chemical structures were identified as phlorigidoside С (1), 8-O-acetylharpagide (2),… read more here.
Keywords: analgesic activities; phlomoides labiosa; sodium; labiosa bunge ... See more keywords
Secondary metabolites from Gentiana cruciata L. and their anti-inflammatory and analgesic activities.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2144301
Abstract: A previously unreported secoiridoid glycoside, cruciatoside (1) was isolated from the aerial parts of Gentiana cruciata L. along with ten known compounds eustomoside (2), eustomorusside (3), gentiopicroside (4), 6'-O-β-D-glucopyranosyl gentiopicroside (5), loganic acid (6), isoorientin… read more here.
Keywords: metabolites gentiana; analgesic activities; gentiana cruciata; anti inflammatory ... See more keywords