Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
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DOI: 10.1021/acs.jmedchem.0c00566
Abstract: The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromodomains of… read more here.
Keywords: anti inflammatory; extraterminal domain; inflammatory antiproliferative; domain bet ... See more keywords
A Mycochemical Investigation of the Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), Reveals Several Lipidic Compounds with Anti-Inflammatory and Antiproliferative Activities.
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DOI: 10.1615/intjmedmushrooms.2021037977
Abstract: A mycochemical investigation on the medicinal mushroom Amauroderma rugosum led to the isolation of 30 compounds, including 14 sterols, 6 phenolic constituents, 5 unsaturated fatty acids, and 5 other compounds. The structures of these compounds… read more here.
Keywords: mushroom amauroderma; mycochemical investigation; inflammatory antiproliferative; amauroderma rugosum ... See more keywords
Bioactive constituents from Gerbera piloselloides with anti-inflammatory and antiproliferative activities.
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DOI: 10.2139/ssrn.4144032
Abstract: A phytochemical investigation of the 95% ethanol extract from Gerbera piloselloides obtained fourteen compounds, including three undescribed phenone-monoterpenes (1a/1b and 2), seven undescribed chromone-monoterpenes (3a/3b-5a/5b and 6), and one undescribed coumarin-monoterpene (8). Among them, four… read more here.
Keywords: inflammatory antiproliferative; antiproliferative activities; gerbera piloselloides; anti inflammatory ... See more keywords