Targeting IL‐34 in inflammatory autoimmune diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28946
Abstract: Interleukin‐34 (IL‐34) shares a common receptor with macrophage colony‐stimulating factor (M‐CSF), and can bind to CSF‐1R, induces lymphocytes differentiation, proliferation, and regulates the synthesis of inflammatory components. Recent findings reported aberrant expression of IL‐34 in… read more here.
Keywords: targeting inflammatory; autoimmune; autoimmune diseases; physiology ... See more keywords
Novel Imidazotriazine Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Disorders.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00139
Abstract: Provided herein are novel imidazotriazine derivatives used as IL-17 modulators, their pharmaceutical compositions, the use of such compounds in treating inflammatory and autoimmune disorders, and processes for preparing such compounds. read more here.
Keywords: inflammatory autoimmune; treating inflammatory; novel imidazotriazine; imidazotriazine derivatives ... See more keywords
Increased cardiovascular comorbidities in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia presenting with systemic inflammatory and autoimmune manifestations.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2018.05.002
Abstract: Myelodysplastic syndromes (MDS) and associated diseases, like chronic myelomonocytic leukemias (CMML), are heterogeneous, clonal disorders affecting the hematopoietic stem cells. They are characterized by dysplasia and a propensity to evolve toward acute myeloid leukemia. Systemic… read more here.
Keywords: myelodysplastic syndromes; cardiovascular comorbidities; autoimmune manifestations; chronic myelomonocytic ... See more keywords
DEL-1: a potential therapeutic target in inflammatory and autoimmune disease?
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1915771
Abstract: Mounting evidence indicates that peripheral tissues and organs have inherent regulatory activity and impact on the host’s immune response; hence, they are not passive targets of inflammatory reactions. Indeed, tissue-derived homeostatic molecules can regulate the… read more here.
Keywords: potential therapeutic; inflammatory autoimmune; therapeutic target; del potential ... See more keywords
Insights into IL‐29: Emerging role in inflammatory autoimmune diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14697
Abstract: Interleukin‐29 (IL‐29) is a newly discovered member of type III interferon. It mediates signal transduction via binding to its receptor complex and activates downstream signalling pathways, and therefore induces the generation of inflammatory components. Recent… read more here.
Keywords: insights emerging; autoimmune diseases; inflammatory; role ... See more keywords
Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases
Sign Up to like & getrecommendations! Published in 2018 at "Military Medical Research"
DOI: 10.1186/s40779-018-0158-5
Abstract: Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette… read more here.
Keywords: risk; hypoxic conditions; cigarette smoke; autoimmune diseases ... See more keywords
Immune-mediated Pathogenesis and Therapies for Inflammatory Autoimmune Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/138161282527191007151037
Abstract: Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Enzymoics, Hebersham, NSW, Australia; Novel Global Community Educational Foundation,… read more here.
Keywords: therapies inflammatory; mediated pathogenesis; autoimmune diseases; pathogenesis therapies ... See more keywords
Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.668131
Abstract: Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR). Targeting of BTK with small… read more here.
Keywords: autoimmune pathologies; btk; inflammatory autoimmune; bruton tyrosine ... See more keywords
IgG subclass and Fc glycosylation shifts are linked to the transition from pre- to inflammatory autoimmune conditions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1006939
Abstract: A crucial factor for the development of inflammatory autoimmune diseases is the occurrence of antibodies directed against self-tissues and structures, which leads to damage and inflammation. While little is known about the cause of the… read more here.
Keywords: igg autoantibody; inflammatory autoimmune; disease; transition pre ... See more keywords
Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1073971
Abstract: Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell. HIF-1α… read more here.
Keywords: inflammatory autoimmune; hypoxia inducible; autoimmune diseases; hif ... See more keywords
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.891328
Abstract: TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial… read more here.
Keywords: tl1a; cell; inflammatory autoimmune; autoimmune diseases ... See more keywords