Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102305
Abstract: Organ‐on‐a‐chip in vitro platforms accurately mimic complex microenvironments offering the ability to recapitulate and dissect mechanisms of physiological and pathological settings, revealing their major importance to develop new therapeutic targets. Bone diseases, such as osteoarthritis,… read more here.
Keywords: innervation; bone; micropathological chip; inflammatory bone ... See more keywords
STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4756
Abstract: Signal transducer and activator of transcription 3 (STAT3), a cytokine‐responsive transcription factor, is known to play a role in immunity and bone remodeling. However, whether and how STAT3 impacts macrophage NLR family pyrin domain containing… read more here.
Keywords: bone; stat3; inflammasome activation; inflammatory bone ... See more keywords
CCL11, a novel mediator of inflammatory bone resorption
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05654-w
Abstract: Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts is perturbed by inflammation. In chronic inflammatory disease with disturbed bone remodelling, e.g. rheumatoid arthritis, patients show increased serum levels of the chemokine… read more here.
Keywords: inflammatory bone; bone; bone resorption; ccl11 ... See more keywords
Glutathione accelerates osteoclast differentiation and inflammatory bone destruction
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2018.1563782
Abstract: Abstract Chronic inflammation associated with bone tissues often destructs bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It… read more here.
Keywords: inflammatory bone; bone; osteoclast differentiation; bone destruction ... See more keywords
FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/8571649
Abstract: Osteoclast (OC) abnormalities lead to many osteolytic diseases, such as osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. Exploring effective strategies to remediate OCs dysregulation is essential. FTY720, also known as fingolimod, has been approved for… read more here.
Keywords: lps induced; osteoclastogenesis; inflammatory bone; bone loss ... See more keywords
Antibacterial-Anti-Inflammatory-Bone Restoration Procedure Achieved by MIN-Loaded PLGA Microsphere for Efficient Treatment of Periodontitis
Sign Up to like & getrecommendations! Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02538-3
Abstract: The main development process of periodontitis involves periodontal pathogenic bacteria as the initiating factor causing the onset of destructive inflammation, which in turn stimulates the destruction of periodontal tissue. It is difficult to achieve the… read more here.
Keywords: anti inflammatory; bone restoration; periodontitis; antibacterial anti ... See more keywords
Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181133
Abstract: TNF-α plays a key role in the development of rheumatoid arthritis (RA) and inflammatory bone loss. Unfortunately, treatment of RA with anti-inflammatory glucocorticoids (GCs) also causes bone loss resulting in osteoporosis. Our previous studies showed… read more here.
Keywords: inflammatory bone; tnf; bone; gilz ... See more keywords
Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.885879
Abstract: Progressive bone loss during aging makes osteoporosis one of the most common and life impacting conditions in geriatric populations. The bone homeostasis is maintained through persistent remodeling mediated by bone-forming osteoblast and bone-resorbing osteoclast. Inflammaging,… read more here.
Keywords: itaconate; bone; bone loss; inflammatory bone ... See more keywords
Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14193978
Abstract: Monotropein (Mon) is a kind of iridoid glycoside plant secondary metabolite primarily present in some edible and medicinal plants. The aim of this study was to investigate the effect of Mon on lipopolysaccharide (LPS)-induced inflammatory… read more here.
Keywords: ocs derived; bone; mon; lps induced ... See more keywords