Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2018-316888
Abstract: Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocytes whereby patients become highly susceptible to bacterial infections. Here, we identify the pathways underlying monocyte dysfunction in ACLF and we investigate whether metabolic rewiring… read more here.
Keywords: monocytes patients; glutamine synthetase; inflammatory capacity; capacity ... See more keywords