Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048937
Abstract: Pyroptosis is a type of acute cell death that mainly occurs in immune cells. It is characterized with robust release of inflammatory cytokines and has emerged to play a critical role in the pathogenesis of… read more here.
Keywords: pyroptosis; selective inhibitor; inflammatory caspases; inhibitor inflammatory ... See more keywords
Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation
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DOI: 10.1016/j.jgr.2019.12.006
Abstract: Inflammation is an immune response that protects against pathogens and cellular stress. The hallmark of inflammatory responses is inflammasome activation in response to various stimuli. This subsequently activates downstream effectors, that is, inflammatory caspases such… read more here.
Keywords: anti inflammatory; medicine; inflammasome activation; roles ginseng ... See more keywords
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes.
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DOI: 10.1146/annurev-immunol-101220-030653
Abstract: Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory… read more here.
Keywords: caspase; inflammasomes inflammatory; immunology; inflammatory caspases ... See more keywords
Focus on the Mechanisms and Functions of Pyroptosis, Inflammasomes, and Inflammatory Caspases in Infectious Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2501279
Abstract: Eukaryotic cells can initiate several distinct self-destruction mechanisms to display essential roles for the homeostasis maintenance, development, and survival of an organism. Pyroptosis, a key response mode in innate immunity, also referred to as caspase-1-dependent… read more here.
Keywords: infectious diseases; pyroptosis; functions pyroptosis; focus mechanisms ... See more keywords