APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.05.17.492361
Abstract: The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response – two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk,… read more here.
Keywords: microglial immunometabolism; inflammatory challenge; pathology; apoe ... See more keywords
Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.846246
Abstract: Inflammation has a role in the pathogenesis of childhood malnutrition. We investigated the effect of malnutrition and inflammatory challenge on bone marrow composition and bone health. We studied an established murine model of moderate acute… read more here.
Keywords: bone marrow; bone; bone health; inflammatory challenge ... See more keywords
Nature-Identical Compounds and Organic Acids Ameliorate and Prevent the Damages Induced by an Inflammatory Challenge in Caco-2 Cell Culture
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25184296
Abstract: Bioactive compounds, such as organic acids (OA) and nature-identical compounds (NIC), can exert a role in the protection of intestinal mucosa functionality due to their biological properties. The aim of this study was to understand… read more here.
Keywords: nature identical; challenge; compounds organic; inflammatory challenge ... See more keywords