Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination
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DOI: 10.1002/advs.202105442
Abstract: Blood–brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption and cellular infiltrates in the brain of MS patients. However, little… read more here.
Keywords: bbb; mir 126a; brain; integrity ... See more keywords
Inflammatory demyelination alters subcortical visual circuits
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DOI: 10.1186/s12974-017-0936-0
Abstract: BackgroundMultiple sclerosis (MS) is an inflammatory demyelinating disease classically associated with axonal damage and loss; more recently, however, synaptic changes have been recognized as additional contributing factors. An anatomical area commonly affected in MS is… read more here.
Keywords: demyelination; synaptic changes; cuprizone model; inflammatory demyelination ... See more keywords