Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
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DOI: 10.1021/acs.jmedchem.1c01948
Abstract: The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING) pathway has been associated with the pathogenesis of many autoimmune and inflammatory disorders, and small molecules targeting STING have emerged as a new therapeutic… read more here.
Keywords: crbn; stimulator interferon; anti inflammatory; proteolysis targeting ... See more keywords