Effect of preoperative biliary drainage on cholestasis‐associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Surgery"
DOI: 10.1002/bjs.11022
Abstract: Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently… read more here.
Keywords: inflammatory fibrotic; perihilar cholangiocarcinoma; drainage; biliary drainage ... See more keywords
Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.112
Abstract: Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients for the first time. However, the adverse effects… read more here.
Keywords: inflammatory fibrotic; fibrosis; microscopy; gps significantly ... See more keywords
Therapeutic potential of NADPH oxidase 1/4 inhibitors
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DOI: 10.1111/bph.13532
Abstract: The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role… read more here.
Keywords: inflammatory fibrotic; oxidase; fibrotic diseases; range ... See more keywords
Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911636
Abstract: Chronic liver inflammation can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Kupffer cells (KC) secrete proinflammatory and fibrogenic cytokines in response to lipopolysaccharide (LPS), and so play an important role in liver inflammation, where they… read more here.
Keywords: evogliptin directly; directly inhibits; inhibits inflammatory; fibrotic signaling ... See more keywords