Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.04.007
Abstract: This study presents BN82002 as an anti-inflammatory drug candidate. It was found that BN82002 inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 cells and peritoneal macrophages that were activated… read more here.
Keywords: anti inflammatory; inflammatory functions; bn82002; akt2 ... See more keywords
A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07565-2
Abstract: Glucocorticoids (GCs)—ligands of the glucocorticoid receptor (GR)—are widely used to treat inflammatory diseases, but suffer from significant side effects and poor responsiveness in certain patient populations. Identification of chemical GR modulators may provide insights into… read more here.
Keywords: anti inflammatory; inflammatory functions; glucocorticoid receptor; high throughput ... See more keywords
Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17560
Abstract: Indirubin, a traditional Chinese medicine formulation from the Muricidae family, has been reported to exhibit abroad anti-cancer and anti-inflammation activities and mediate nuclear factor-κB (NF-κB) signal. Thus, this study aimed to investigate the protective effects… read more here.
Keywords: anti inflammatory; antioxidant anti; improves antioxidant; inflammatory functions ... See more keywords
Not only myelination: the immune-inflammatory functions of oligodendrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.342678
Abstract: Oligodendrocytes (OLs) are highly specialized cells of the central nervous system (CNS). Their primary and most investigated role is to form myelin, a multilamellar fatty membrane that enwraps axons ensuring their insulation and the saltatory… read more here.
Keywords: functions oligodendrocytes; inflammatory functions; immune inflammatory; myelin ... See more keywords