How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14409
Abstract: Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid receptor (GR), which regulates transcription of distinct gene networks in… read more here.
Keywords: mechanisms inflammatory; tame genes; genes mechanisms; repression ... See more keywords
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67000-x
Abstract: Despite extensive investigations, an effective treatment for sepsis remains elusive and a better understanding of the inflammatory response to infection is required to identify potential new targets for therapy. In this study we have used… read more here.
Keywords: response; inflammatory gene; gene expression; expression ... See more keywords
An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43315
Abstract: Neurofibromas are benign peripheral nerve tumors driven by NF1 loss in Schwann cells (SCs). Macrophages are abundant in neurofibromas, and macrophage targeted interventions may have therapeutic potential in these tumors. We generated gene expression data… read more here.
Keywords: type interferon; inflammatory gene; schwann cells; scs macrophages ... See more keywords
Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000003658
Abstract: A mouse model of cecal slurry-induced sepsis was used to evaluate lyophilized plasma (LP) as an initial resuscitation fluid. LP downregulated pulmonary inflammatory gene signaling pathways but did not affect mortality or other physiologic endpoints.… read more here.
Keywords: sepsis; lyophilized plasma; inflammatory gene; model ... See more keywords
P115 Cigarettes smoke extract induces inflammatory gene expression in human bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210983.257
Abstract: Background Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder of the respiratory tract characterised by airflow obstruction. It is increasingly recognised that the innate immune pattern-recognition receptors may contribute to airway inflammation in COPD… read more here.
Keywords: inflammatory gene; gene expression; cse; expression ... See more keywords
AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of innate immunity"
DOI: 10.1159/000517627
Abstract: Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response. However, excessive TLR2 activation can lead to inappropriate inflammation, which contributes to… read more here.
Keywords: response; inflammatory gene; ahr; gene expression ... See more keywords
BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.138687
Abstract: The bromodomain and extraterminal (BET) family of epigenetic reader proteins are key regulators of inflammatory and hypertrophic gene expression in the heart. We previously identified the activation of pro-inflammatory gene networks as a key early… read more here.
Keywords: bet bromodomain; inflammatory gene; bet; gene ... See more keywords
Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18813
Abstract: Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations… read more here.
Keywords: tnf; tnf 238g; inflammatory gene; gene polymorphisms ... See more keywords
The Modulatory Effect of Lead Drug Candidates on Inflammatory Gene Expression in Sepsis: A Mini-Review.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug discovery technologies"
DOI: 10.2174/1570163815666180227162926
Abstract: Sepsis is a debilitating clinical syndrome of systemic inflammation in response to microorganisms especially Gram-positive and Gram-negative bacteria. A minority of sepsis cases could be due to non-pathogenic insult such as trauma. Much of the… read more here.
Keywords: sepsis; inflammatory gene; drug candidates; gene expression ... See more keywords
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01859
Abstract: For many decades, glucocorticoids have been widely used as the gold standard treatment for inflammatory conditions. Unfortunately, their clinical use is limited by severe adverse effects such as insulin resistance, cardiometabolic diseases, muscle and skin… read more here.
Keywords: gene regulation; mechanisms inflammatory; inflammatory gene; gene ... See more keywords
The Effects of Antioxidant Supplements on the Inflammatory Gene Expression of Osteoarthritis-Like Chondrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Applied Sciences"
DOI: 10.3390/app11010239
Abstract: Osteoarthritis patients often experience pain and inflammation in joints. To understand whether antioxidant supplements could reduce inflammation and could potentially be applied for osteoarthritis treatment, vitamin E and resveratrol were investigated in this study. Hydrogen… read more here.
Keywords: antioxidant supplements; osteoarthritis like; inflammatory gene; vitamin resveratrol ... See more keywords