Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genes.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.03.003
Abstract: Genomic transposable elements (TEs) constitute the majority of the genome. Expression of TEs is known to activate the double-stranded RNA recognition pathway ("viral mimicry"), leading to the activation of interferon-stimulated genes, inflammation, and immune-mediated cell… read more here.
Keywords: expression tes; senescence; human hematopoietic; inflammatory genes ... See more keywords
Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0104-9
Abstract: Deletion of the Casp8 gene in epithelial tissues of mice results in severe inflammatory pathologies. Its ubiquitous deletion, or its specific deletion in endothelial cells, results in intrauterine death associated with capillary damage. These pathologies… read more here.
Keywords: deletion; inflammatory genes; activation inflammatory; caspase deficiency ... See more keywords
Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01569-2
Abstract: The glucocorticoid (GC) receptor (GR) suppresses inflammation by activating anti-inflammatory and repressing pro-inflammatory genes. GR-interacting protein-1 (GRIP1) is a GR corepressor in macrophages, however, whether GRIP1 mediates GR-activated transcription, and what dictates its coactivator versus… read more here.
Keywords: anti inflammatory; cdk9; inflammatory genes; grip1 ... See more keywords
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx509
Abstract: Abstract The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes.… read more here.
Keywords: protein; inflammatory genes; dna binding; binds directly ... See more keywords
Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-017-0332-1
Abstract: BackgroundEstrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes and estradiol levels on… read more here.
Keywords: risk ischemic; ischemic stroke; estradiol levels; inflammatory genes ... See more keywords
Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0177224
Abstract: We have analyzed the complex pattern of the inflammatory response in early-onset canine models of human retinitis pigmentosa, rcd1, xlpra2 and erd, as well as late-onset xlpra1, in comparative manner. The time course of immune… read more here.
Keywords: canine models; early onset; response; inflammatory genes ... See more keywords