Variable transcriptional responsiveness of the P2X3 receptor gene during CFA‐induced inflammatory hyperalgesia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26534
Abstract: The purinergic receptor P2X3 (P2X3‐R) plays important roles in molecular pathways of pain, and reduction of its activity or expression effectively reduces chronic inflammatory and neuropathic pain sensation. Inflammation, nerve injury, and cancer‐induced pain can… read more here.
Keywords: p2x3; inflammatory hyperalgesia; cfa; receptor ... See more keywords
G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-1000-3
Abstract: Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the… read more here.
Keywords: chronic hyperalgesia; inflammatory hyperalgesia; hyperalgesia; threshold regulator ... See more keywords
Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00473
Abstract: Peripheral inflammatory hyperalgesia depends on the sensitization of primary nociceptive neurons. Inflammation drives molecular alterations not only locally but also in the dorsal root ganglion (DRG) where interleukin-1 beta (IL-1β) and purinoceptors are upregulated. Activation… read more here.
Keywords: drg; peripheral inflammatory; inflammatory hyperalgesia; hyperalgesia ... See more keywords
TRPV1 Responses in the Cerebellum Lobules V, VIa and VII Using Electroacupuncture Treatment for Inflammatory Hyperalgesia in Murine Model
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21093312
Abstract: Inflammatory pain sensation is an important symptom which protects the body against additional tissue damage and promotes healing. Discovering long-term and effective treatments for pain remains crucial in providing efficient healthcare. Electroacupuncture (EA) is a… read more here.
Keywords: inflammatory hyperalgesia; inflammatory; lobules via; cfa ... See more keywords
A Short-Chain Fatty Acid, Butyrate, Suppresses the Hyperexcitability of Rat Nociceptive Primary Neurons Involved in Inflammatory Hyperalgesia
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30112407
Abstract: While gut microbiota-derived short-chain fatty acids (SCFAs) are recognized to modulate pathological pain by decreasing inflammation, the neurophysiological basis for SCFAs, butyrate’s ability to reduce hyperexcitability in nociceptive primary neurons during inflammatory conditions is still… read more here.
Keywords: inflammatory hyperalgesia; hyperexcitability; nociceptive primary; butyrate ... See more keywords
Naringenin Suppresses the Hyperexcitability of Trigeminal Nociceptive Neurons Associated with Inflammatory Hyperalgesia: Replacement of NSAIDs with Phytochemicals
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16223895
Abstract: The present study examines whether the systemic application of naringenin (NRG) reduces inflammation-induced hyperexcitability in the spinal trigeminal nucleus caudalis (SpVc) related to hyperalgesia, and compares its impact with that of diclofenac (DIC). To provoke… read more here.
Keywords: inflammatory hyperalgesia; inflamed rats; administration; hyperalgesia ... See more keywords